ID   W0GMA9_9MOLU            Unreviewed;      1014 AA.
AC   W0GMA9;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=P344_05585 {ECO:0000313|EMBL:AHI58436.1};
OS   Spiroplasma mirum ATCC 29335.
OC   Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC   Spiroplasma.
OX   NCBI_TaxID=838561 {ECO:0000313|EMBL:AHI58436.1, ECO:0000313|Proteomes:UP000019260};
RN   [1] {ECO:0000313|EMBL:AHI58436.1, ECO:0000313|Proteomes:UP000019260}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMCA {ECO:0000313|EMBL:AHI58436.1,
RC   ECO:0000313|Proteomes:UP000019260};
RA   Landry C.A., Bastian F.O., Thune R.L.;
RT   "Complete genome sequence of Spiroplasma mirum suckling mouse cataract
RT   agent.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR   EMBL; CP006720; AHI58436.1; -; Genomic_DNA.
DR   RefSeq; WP_051413791.1; NZ_CP002082.1.
DR   AlphaFoldDB; W0GMA9; -.
DR   STRING; 838561.P344_05585; -.
DR   KEGG; smia:P344_05585; -.
DR   KEGG; smir:SMM_0942; -.
DR   PATRIC; fig|838561.3.peg.1076; -.
DR   eggNOG; COG0587; Bacteria.
DR   HOGENOM; CLU_001600_0_1_14; -.
DR   OrthoDB; 9803237at2; -.
DR   Proteomes; UP000019260; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd07431; PHP_PolIIIA; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019260};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          4..70
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1014 AA;  117259 MW;  807FFA91FA88D2F8 CRC64;
     MAKMHLNVRT NYSLLSSLIG IDNYLAYGQT NGLPALAICD NNMYGVYEFH EKCCSHNITP
     IIGLNFYTYF NNQKYNLNLF AINQAGYFNL VKISSWIMTN NEKDNVIDFS TLLPFINDHL
     KIIINFEEVN YDVVFYQKLL TMLNNPDNLY LGLNNNNLML LSFFKELVTN DKIIWNNKVL
     YFDNTDFNAY KIINAIKKQI LFKESMVKDT FAFDNYSSEY EQYLDNISAF ISNIQGYDLK
     HQNIHDNLLK YPTPENVASR DFLRGVCKKG MKYKLGSHVE NKYLVRLKYE LDIIDQMDFN
     DYFLIVWDYV NFAKKNNIYV GPGRGSAAGS LVSYLLDITT IDPVQENLIF ERFLNPERQG
     MPDIDIDFQD DKREAVVEYL FEKYGQQHIA HIVTFQTSGM KMALRDVCRV FGISLEEADK
     MSKAVRLEDN YNFTNAFTNN NVLDFYSKKY PHIFLYLPKI VGLPRQTGTH AAGVVLSQKP
     LATVVPIREG YNGIYQTQYS MNYLEELGLL KMDLLGLRNL TILHNVINNI YQEIKVKINL
     QKIPLNDAKT FKLLSSGDTK GIFQLESPGM TKVLIEMQPD KLEDIVATSS LYRPGPQDNI
     PLYIQRKNHH VKFSYLDDRL KDILAPTYGI IVYQEQVMLI AQKVANFSLA KADILRRAMG
     KKESSYMNEL KTEFLNNAVK NHYTPEIAND IWNLIYKFAA YGFNRSHAVA YSLLGYQMAY
     LKANYPSQFL ASLLTNVIGD ENKTADYIQL ARKNNLGILP PSIILPLSTY VTRDDKICLP
     LLVIKQIGYA FYNKIAQEYH ERGEFQDLYD IFIRLYKKGL NKKTYEALCY TGALDYLNFN
     RTTLFNNYNL LANYVEVIKV SENNEQLIIN PHLAEKPEVV IFEDDVINNI KKEYEFLGFY
     LSNHPLKYIR TLGDYEQKTT LISDLKLSQG TTNILVIIKR VKEIFDKNNK KMAFVDCYDE
     SGAISITVFA NKYQQYAVLL KPNNVILLNI KLGSYQDKIN GIMNRIKLIT TENK
//