ID W0HXM0_9GAMM Unreviewed; 777 AA.
AC W0HXM0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149,
GN ECO:0000313|EMBL:AHF78499.1};
GN ORFNames=Sant_3512 {ECO:0000313|EMBL:AHF78499.1};
OS Sodalis praecaptivus.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Bruguierivoracaceae; Sodalis.
OX NCBI_TaxID=1239307 {ECO:0000313|EMBL:AHF78499.1, ECO:0000313|Proteomes:UP000019028};
RN [1] {ECO:0000313|EMBL:AHF78499.1, ECO:0000313|Proteomes:UP000019028}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HS1 {ECO:0000313|EMBL:AHF78499.1,
RC ECO:0000313|Proteomes:UP000019028};
RX PubMed=24407854; DOI=10.1093/gbe/evt210;
RA Oakeson K.F., Gil R., Clayton A.L., Dunn D.M., von Niederhausern A.C.,
RA Hamil C., Aoyagi A., Duval B., Baca A., Silva F.J., Vallier A.,
RA Jackson D.G., Latorre A., Weiss R.B., Heddi A., Moya A., Dale C.;
RT "Genome degeneration and adaptation in a nascent stage of symbiosis.";
RL Genome Biol. Evol. 6:76-93(2014).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; CP006569; AHF78499.1; -; Genomic_DNA.
DR RefSeq; WP_025423620.1; NZ_CP006569.1.
DR AlphaFoldDB; W0HXM0; -.
DR KEGG; sod:Sant_3512; -.
DR PATRIC; fig|1239307.3.peg.3869; -.
DR HOGENOM; CLU_004131_5_1_6; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000019028; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000019028}.
FT DOMAIN 212..329
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 600..735
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 336..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 83659 MW; F9F29BD953763471 CRC64;
MPIQVLPPQL ANQIAAGEVV ERPASVVKEL LENSLDAGAT RIEIDIERGG AKRIRIRDNG
SGIAKEELAL ALARHATSKI ASLDDLESIT SMGFRGEALA SVSSVSRLTL TSRTAAQSEA
WQAYAEGREL AVTLKPAAHP VGTTADVVDL FYNTPARRKF MRTEKTEFTH IDEVIRRIAL
ARFDVTFILQ HNGKTVRQYR AVSQQSQHLR RLGGLCGPAF VARALSVSWQ HGDLAIHGWV
ADPAGGELPE IQYSYVNRRT MRDKLINHAI RQAYQDQLAG TQQPAFVLFL DVDPHQVDVN
VHPAKHEVRF HQARLVHDFI YQAVVTVLQQ SGAPRLPIGD EGAGPSAPEN RQASGRNHFS
LPAGEASSLW GARQPDGEPS RLPEDAAASG LAAARPALVA ADEERRAASE TGGDSEHDRR
SAAAVKDSEH GHRSSAVVDS EHGHRSSAVV DSEHDQRSVA VDGDSRHDRR SVAAGGNSDR
DRRSAGVADE RASPQHSSGA AARGGQARER SGGYAGGAGY QRKEGALYRQ LVQTAPLAQE
GQTTPRDIFA RPRPADGGSL PGDNDAPHAG AAASSSAVMG EASVSAGPAV AGNPHSFGRV
VTLVAPCYAL VESASGLALL SLPVAERGLT ERQLTPGTEQ LRAQPLLIPL RMTLRDEEAA
ALKRHQPLLQ EMGITLQAHL HQAILNAVPL PLRQQNLQNL IPDLLGYLHG ETSVTHHQVA
VWLARRLQHE SVVWSHSRAI QLLAEVERLC PQWVKAPPDG LLVTLNFEAA IKALNHD
//
