ID W0HZ56_9GAMM Unreviewed; 336 AA.
AC W0HZ56;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein {ECO:0000313|EMBL:AHF77480.1};
GN ORFNames=Sant_2438 {ECO:0000313|EMBL:AHF77480.1};
OS Sodalis praecaptivus.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Bruguierivoracaceae; Sodalis.
OX NCBI_TaxID=1239307 {ECO:0000313|EMBL:AHF77480.1, ECO:0000313|Proteomes:UP000019028};
RN [1] {ECO:0000313|EMBL:AHF77480.1, ECO:0000313|Proteomes:UP000019028}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HS1 {ECO:0000313|EMBL:AHF77480.1,
RC ECO:0000313|Proteomes:UP000019028};
RX PubMed=24407854; DOI=10.1093/gbe/evt210;
RA Oakeson K.F., Gil R., Clayton A.L., Dunn D.M., von Niederhausern A.C.,
RA Hamil C., Aoyagi A., Duval B., Baca A., Silva F.J., Vallier A.,
RA Jackson D.G., Latorre A., Weiss R.B., Heddi A., Moya A., Dale C.;
RT "Genome degeneration and adaptation in a nascent stage of symbiosis.";
RL Genome Biol. Evol. 6:76-93(2014).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP006569; AHF77480.1; -; Genomic_DNA.
DR RefSeq; WP_025422627.1; NZ_CP006569.1.
DR AlphaFoldDB; W0HZ56; -.
DR KEGG; sod:Sant_2438; -.
DR PATRIC; fig|1239307.3.peg.2717; -.
DR HOGENOM; CLU_019796_1_2_6; -.
DR OrthoDB; 9805416at2; -.
DR Proteomes; UP000019028; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12156; HPPR; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000019028}.
FT DOMAIN 62..332
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 129..301
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 336 AA; 35272 MW; FD3B8538C67CF333 CRC64;
MTVRLLSHID VPPAHRPAFA AAGVTLYLAP RADPNGPLWP DGPLRPVPAT AAQGSVEDEV
FDAAAIDVLL TIGSLGISAQ EMDKLPALRL ICCLGVGYER VDLAAAAARG IRVTHGRGTN
DTSVADHAMA LMLALVRDIA PLDRAVRRGQ WQQSRRLRPQ LSGKRVGILG LGTIGANIAE
RCARGFAMEV GYHNRRPKAD CAYHYCSSAT VLAQWCEILV IATPGGAATR HLVDEGVLTA
LGAEGFLVNI ARGSVVDTAA LTAALQAQAI AGAALDVIEG EPQVPPALLA QDNVLITPHV
AARSPQAMTA MYRQMLENLA CHLNGQPLLT PVAAGE
//
