ID   W0I531_9EURY            Unreviewed;       753 AA.
AC   W0I531;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN   ORFNames=TES1_1799 {ECO:0000313|EMBL:AHF81174.1};
OS   Thermococcus paralvinellae.
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=582419 {ECO:0000313|EMBL:AHF81174.1, ECO:0000313|Proteomes:UP000019027};
RN   [1] {ECO:0000313|EMBL:AHF81174.1, ECO:0000313|Proteomes:UP000019027}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ES1 {ECO:0000313|EMBL:AHF81174.1,
RC   ECO:0000313|Proteomes:UP000019027};
RX   PubMed=25082851; DOI=10.1099/ijs.0.066100-0;
RA   Hensley S.A., Jung J.H., Park C.S., Holden J.F.;
RT   "Thermococcus paralvinellae sp. nov. and Thermococcus cleftensis sp. nov.
RT   of hyperthermophilic heterotrophs from deep-sea hydrothermal vents.";
RL   Int. J. Syst. Evol. Microbiol. 64:3655-3659(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP006965; AHF81174.1; -; Genomic_DNA.
DR   RefSeq; WP_042682219.1; NZ_CP006965.1.
DR   AlphaFoldDB; W0I531; -.
DR   STRING; 582419.TES1_1799; -.
DR   GeneID; 24906186; -.
DR   KEGG; ths:TES1_1799; -.
DR   HOGENOM; CLU_008861_2_0_2; -.
DR   OrthoDB; 42357at2157; -.
DR   Proteomes; UP000019027; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   NCBIfam; TIGR00921; 2A067; 1.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        210..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        236..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        266..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        308..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        336..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        594..610
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        617..639
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        645..664
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        685..707
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        719..742
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          235..361
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   DOMAIN          615..740
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   753 AA;  84046 MW;  4C0FDBF0F0D1B60D CRC64;
     MLKKLAKIIV EYRVAFGLVA IFLLIVSLYG ITQLKFETNL ANQLPENLPA VQDYFTVQNE
     FQSNEVLIVV VKVKDIKEGG VYDIRDPQVI QGIYDLEQKL RQHEYITNTM SIADVYINVL
     GRLPKSMEES KFVLNMLPED VRNQLISSDY TTTLIIATMN REKNTQALVR VYNEIQDDID
     SVKFPQNVEV VQTGMVGILY KFLLFMQHDM YLTMAIAFLF VASLLLYFYR SSVKAVIPLI
     PLIFGVIMTL GFMGILGVPL DIETTTVGAM LVGMGIDYGV HVTNRYYEER KKGRSIEEAA
     EESIAETGKA LLGAALTTIA GFSALSISVL PGLRRLSLAL IMGLGLAALN AVVITPAIII
     LEEDLRKLIT GHYEMPETRS HSGFIAQAFE LMGKTVRDNP WKFLALVFVI TLFFGYGLTM
     VTTEVRFEKM IPQNIPEIQV MNDVRYEFGG EDELDVLVKA ADDVRDPNVV RAIYVFEQSI
     LADSYYNNAV EAESIADIVI KKYGYIPEDK EKIQQALEEY QGTPLVSSDY SMTLIRFKGN
     FMGVSQDEFR KIIRAFEEEI QNAEFPPGVE VSLAGDTYLN YALDKLTNTE LQRISTYGTL
     LVVLIVILLF RSAKLSIAMA TPMFLGALWT IGFMGWAGIP FSQVLAGTIS MIVGLGVDYG
     MHLTHRFMEE LEEGNPYPIV TAVKSVGPGI FIGALTTAGG FLALLFGELT PMHDFGKTLA
     FGIFASMLAS YLVTPALLQI FYGKQIKRRG EEE
//