ID   W0IYL2_9BACT            Unreviewed;       880 AA.
AC   W0IYL2;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=beta-mannosidase {ECO:0000256|ARBA:ARBA00012754};
DE            EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
GN   ORFNames=OPIT5_05770 {ECO:0000313|EMBL:AHF89818.1};
OS   Opitutaceae bacterium TAV5.
OC   Bacteria; Verrucomicrobiota; Opitutae; Opitutales; Opitutaceae.
OX   NCBI_TaxID=794903 {ECO:0000313|EMBL:AHF89818.1, ECO:0000313|Proteomes:UP000003813};
RN   [1] {ECO:0000313|EMBL:AHF89818.1, ECO:0000313|Proteomes:UP000003813}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TAV5 {ECO:0000313|EMBL:AHF89818.1};
RX   PubMed=25744998;
RA   Kotak M., Isanapong J., Goodwin L., Bruce D., Chen A., Han C.S.,
RA   Huntemann M., Ivanova N., Land M.L., Nolan M., Pati A., Woyke T.,
RA   Rodrigues J.L.;
RT   "Complete Genome Sequence of the Opitutaceae Bacterium Strain TAV5, a
RT   Potential Facultative Methylotroph of the Wood-Feeding Termite
RT   Reticulitermes flavipes.";
RL   Genome Announc. 3:0-0(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC         in beta-D-mannosides.; EC=3.2.1.25;
CC         Evidence={ECO:0000256|ARBA:ARBA00000829};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC       {ECO:0000256|ARBA:ARBA00007401}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP007053; AHF89818.1; -; Genomic_DNA.
DR   AlphaFoldDB; W0IYL2; -.
DR   STRING; 794903.OPIT5_05770; -.
DR   KEGG; obt:OPIT5_05770; -.
DR   eggNOG; COG3250; Bacteria.
DR   HOGENOM; CLU_005015_3_2_0; -.
DR   OrthoDB; 9801077at2; -.
DR   Proteomes; UP000003813; Chromosome.
DR   GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProt.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR   InterPro; IPR041625; Beta-mannosidase_Ig.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR   PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR   Pfam; PF00703; Glyco_hydro_2; 1.
DR   Pfam; PF17753; Ig_mannosidase; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AHF89818.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003813}.
FT   DOMAIN          198..331
FT                   /note="Glycoside hydrolase family 2 immunoglobulin-like
FT                   beta-sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF00703"
FT   DOMAIN          813..878
FT                   /note="Beta-mannosidase Ig-fold"
FT                   /evidence="ECO:0000259|Pfam:PF17753"
FT   REGION          255..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   880 AA;  100068 MW;  A9B64F4BA2075E0E CRC64;
     MTTLDLASSA GLAGWRFRDT SKKTWLPAQV PGCVHTDLIR EEKIPDPFYG THELDLQWIE
     ERDWEYTATF NVPASLFDDE QIDLVADGLD TVATVFLNGK KIAATENMFT GYRWPVKKLL
     RRGRNELRIH FRSAMDYIRS VRPEHTPREC NDPVGGCTRV RKMQCNFGWD WGPRLVTAGV
     WRDIRLEGWG ANRLVHAHIA QTHAPDGSVT LTVTPELAMD APVSVEVRVT LDGKDVARAF
     SAKRPLPWHG LPAREVPEAR RVAPRRSGRN AAAPTAGGTP APLTEPITLS IPDPQLWWPA
     GQGKQPLYDV EIIASSGDEK LNTIRKRIGL RTLVLDRHPD EWGESFRFVV NGRPVFIKGA
     NWIPAHAFVA GLTRADYARD LRAAALANMN CVRLWGGGIY ESEHFYDLCD ELGLLVWHDF
     MFGCTLYPYD DAFVESVRVE AVYNVRRVHH RASLALWCGN NELVQINKPR ILDTPEHKAG
     YERIFHDLLP AVIAEHDGTT PYWPSSEWSG DWETGHEVFE KRGDKHFWDV WHARKPVKDY
     EKYAFRFVSE FGMQSYSSPE TNATFCPADD DNVFGPTMEN HQKNRAGNQI ILDYVSRRYR
     LPKSQDDLIW LSQLNQAYCM QVGIEHYRRL APRCMGTIYW QLNDCWPVAS WSSIEFTGRW
     KALHYAARRF NAPALVTAHV PGDETPVIGN YRRTTVREVH LHTVYDAPVP ARGVLRWDLF
     RIDARAGGTK KVKSLLSGKK SVTLRYGESV NQKTLDLGAA MERYGRDNIY LRIALDVGGR
     TVSEDTVFLA PPRFLPLPRA KTRVRVRQLG PKEFAVAFTS PVFQHRFAFG LPGLAHMADD
     NWFELYPGEP KEVIVTLARP ATKATVEKKL RYRSLADTYA
//