ID W0IYY8_9BACT Unreviewed; 779 AA.
AC W0IYY8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Sodium/hydrogen exchanger {ECO:0000313|EMBL:AHF89938.1};
GN ORFNames=OPIT5_06615 {ECO:0000313|EMBL:AHF89938.1};
OS Opitutaceae bacterium TAV5.
OC Bacteria; Verrucomicrobiota; Opitutae; Opitutales; Opitutaceae.
OX NCBI_TaxID=794903 {ECO:0000313|EMBL:AHF89938.1, ECO:0000313|Proteomes:UP000003813};
RN [1] {ECO:0000313|EMBL:AHF89938.1, ECO:0000313|Proteomes:UP000003813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TAV5 {ECO:0000313|EMBL:AHF89938.1};
RX PubMed=25744998;
RA Kotak M., Isanapong J., Goodwin L., Bruce D., Chen A., Han C.S.,
RA Huntemann M., Ivanova N., Land M.L., Nolan M., Pati A., Woyke T.,
RA Rodrigues J.L.;
RT "Complete Genome Sequence of the Opitutaceae Bacterium Strain TAV5, a
RT Potential Facultative Methylotroph of the Wood-Feeding Termite
RT Reticulitermes flavipes.";
RL Genome Announc. 3:0-0(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
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DR EMBL; CP007053; AHF89938.1; -; Genomic_DNA.
DR AlphaFoldDB; W0IYY8; -.
DR STRING; 794903.OPIT5_06615; -.
DR KEGG; obt:OPIT5_06615; -.
DR eggNOG; COG0475; Bacteria.
DR eggNOG; COG0490; Bacteria.
DR HOGENOM; CLU_020579_0_0_0; -.
DR OrthoDB; 9781411at2; -.
DR Proteomes; UP000003813; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 2.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 2.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
DR PROSITE; PS51202; RCK_C; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003813};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 61..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 588..672
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
FT DOMAIN 675..759
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 779 AA; 83783 MW; A959A81A85247412 CRC64;
MEHYNLIKDL GTVLLAGGLA GIICKRLGLS AIVGYLVAGM VIGPHTPPFS LIAEEERIRE
LSEVGLVFVM FAIGLHLSLS KLGKLGLATI GATFLGAFFM LNFTLILGHF LDWTAMQSMF
VAAMLMVSSS AVIAKLMQEY NLNHDRAAQM ALAITIVEDV VAVIMLTLLV SHETGGGGVG
GVVGVLGAFV VLLIGGGLLL MPRLLRRLEA KGDPEIQTVV VAGLLLIMAF LTIKAGYSLA
LGAFLFGAVV AEMRQKNAIE KSFESIRYLF SSVFFVSIGM MINLEQLKEV WLTVLILCTF
SLVFRPIACG FALILVGISP REARRGGLLL TPLGEFTFII AAAGIGASIL PSTFYPLAVS
LSVLTVLVTP ILNRYAEPIL KFADWVEPRW VTRAITAYHG WLKQLQSRPS PALAWKLIRG
RAFQVGIEVM FVSGLLIFSG QILAALEKSV VSEWLSERTF RYVFWSVIGI AVLVPLVAVW
RNLSAMALIL AEALGGTGSD RSLPKRVLEH GFKGAAGLGM LYWLYAILPV AALPGWGWAV
IACVAVVLAV VFSNRLIYWH SSWEHSVQEV LAEDSRRPEE VRADARVALD ESLGAWKLRL
EECVVPDAAS YAGHTLAQLS IPARFGCSVL EVERNGHLIT GAGPDLRLYP GDKILLLGAR
ESLDAVHVFL QARKPHASAD DEFGGSVLET CVVPTTLRGG RTLAEWQFAR DTGVRIAGIR
RGGEQILTPG GSQTLEPGDD LLVVGSLGEL RAFRQWLKSA ASPAPVAEAG GATEVATAG
//
