ID W0JTT9_9EURY Unreviewed; 830 AA.
AC W0JTT9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Hef nuclease {ECO:0000313|EMBL:AHG00660.1};
GN ORFNames=HALLA_19570 {ECO:0000313|EMBL:AHG00660.1};
OS Halostagnicola larsenii XH-48.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Halostagnicola.
OX NCBI_TaxID=797299 {ECO:0000313|EMBL:AHG00660.1, ECO:0000313|Proteomes:UP000019024};
RN [1] {ECO:0000313|EMBL:AHG00660.1, ECO:0000313|Proteomes:UP000019024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XH-48 {ECO:0000313|EMBL:AHG00660.1,
RC ECO:0000313|Proteomes:UP000019024};
RG DOE Joint Genome Institute;
RA Anderson I., Huntemann M., Han J., Chen A., Kyrpides N., Mavromatis K.,
RA Markowitz V., Palaniappan K., Ivanova N., Schaumberg A., Pati A.,
RA Liolios K., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP007055; AHG00660.1; -; Genomic_DNA.
DR RefSeq; WP_049953912.1; NZ_CP007055.1.
DR AlphaFoldDB; W0JTT9; -.
DR STRING; 797299.HALLA_19570; -.
DR GeneID; 25146587; -.
DR KEGG; hlr:HALLA_19570; -.
DR PATRIC; fig|797299.3.peg.2909; -.
DR eggNOG; arCOG00872; Archaea.
DR HOGENOM; CLU_002513_3_1_2; -.
DR OrthoDB; 9764at2157; -.
DR Proteomes; UP000019024; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd12089; Hef_ID; 1.
DR CDD; cd20075; XPF_nuclease_XPF_arch; 1.
DR Gene3D; 3.40.50.10130; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 1.20.1320.20; hef helicase domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR006166; ERCC4_domain.
DR InterPro; IPR041755; Hef_ID.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR14025; FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER; 1.
DR PANTHER; PTHR14025:SF20; FANCONI ANEMIA GROUP M PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF02732; ERCC4; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF21210; RNA_helicase_helical; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00891; ERCC4; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000019024}.
FT DOMAIN 30..197
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 361..524
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 318..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 91539 MW; 1358CB116CDAB1D5 CRC64;
MAATDEEIPS IDHPLLEPNF LERRLYQLKL AGTAANDHTL VCLPTGLGKT TVSLLVTARR
LEEVGGKSLM LAPTKPLVQQ HAEFYREALQ IPDEEIVVFT GDVSPDDRAA LWNESTVIMA
TPQVIENDLV GSRVSLSDVT HITFDECHRA TGDYAYNYIA ERYHADANQP LVTGMSASPG
GDEEAILEVC ENLGLHEVEV MTEEDADVSE FTHDTDVEWE RIDLPEDVIE IRDALNEVIT
ERLEKLKELG IAKSTQPDQS QKDLNRMRAE LQELINNDQS EGFKGMSVHA EVMKLRQAVT
LVETQSVEAL RRYFDRQRNQ ARSSGASKAS QRLVSDPRVK ESMRKAEKYD ELHPKYRKTR
MLLAETLGLE GGERVIVFTE SRDTAEALTD FLDDSFDAKR FVGQGDREGS DGMTQTQQQD
VLNDFRAGEF EVLVSTSVAE EGLDVPEVDL VLFYEPVPTA IRSIQRKGRT GRQSEGRVVV
LMAEDTRDEA YFWISRRREK EMESELRELK GMADDLKEEL DDAQQSLAAF ESGGEGTGES
GDSSTNESEV EVNDGRQKPP DGDISSSGSE GVADRPGLRE FDGSDGDDGG DPTDEAADAE
VEPREPHADG DAIEIVADQR EMDANIAREL SKREDVEIRL ETLEVGDYVL SDRAVVERKS
VADFVDSLVG GDRSVFEQVG AMARHYSRPI VIVEGDGLYE QRDVHPNAVR GALSSLAVDF
GASVLRTEDE TDTKELLGVI AGREQETSNR EVSVHGEKQS KTLAEQQEYV VGSIAEIGPV
TARSLLEEFG TVEAVMIASE DELQAADGVG SVTAARIREV IGSDYTGSGK
//
