ID W0L8V3_9GAMM Unreviewed; 389 AA.
AC W0L8V3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0000256|ARBA:ARBA00019465};
GN ORFNames=Z042_01085 {ECO:0000313|EMBL:AHG18395.2};
OS Chania multitudinisentens RB-25.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Chania.
OX NCBI_TaxID=1441930 {ECO:0000313|EMBL:AHG18395.2, ECO:0000313|Proteomes:UP000019030};
RN [1] {ECO:0000313|EMBL:AHG18395.2, ECO:0000313|Proteomes:UP000019030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RB-25 {ECO:0000313|EMBL:AHG18395.2,
RC ECO:0000313|Proteomes:UP000019030};
RA Robson E.H.J.;
RT "Isolation of Serratia multitudinisentens RB-25 from Ex-Landfill site.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AHG18395.2, ECO:0000313|Proteomes:UP000019030}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RB-25 {ECO:0000313|EMBL:AHG18395.2,
RC ECO:0000313|Proteomes:UP000019030};
RA Chan K.-G.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH;
CC Xref=Rhea:RHEA:16233, ChEBI:CHEBI:11561, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.169; Evidence={ECO:0000256|ARBA:ARBA00000784};
CC -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-
CC pantoate from 3-methyl-2-oxobutanoate: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004994}.
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DR EMBL; CP007044; AHG18395.2; -; Genomic_DNA.
DR RefSeq; WP_024910949.1; NZ_JAJC01000006.1.
DR AlphaFoldDB; W0L8V3; -.
DR STRING; 1441930.Z042_01085; -.
DR KEGG; sfo:Z042_01085; -.
DR eggNOG; COG0240; Bacteria.
DR HOGENOM; CLU_041606_1_0_6; -.
DR OrthoDB; 7328149at2; -.
DR UniPathway; UPA00028; UER00004.
DR Proteomes; UP000019030; Chromosome.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003421; Opine_DH.
DR PANTHER; PTHR38015; BLR6086 PROTEIN; 1.
DR PANTHER; PTHR38015:SF1; OCTOPINE_DH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF02317; Octopine_DH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pantothenate biosynthesis {ECO:0000256|ARBA:ARBA00022655};
KW Reference proteome {ECO:0000313|Proteomes:UP000019030}.
FT DOMAIN 9..110
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 196..366
FT /note="Opine dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF02317"
SQ SEQUENCE 389 AA; 42579 MW; A731B2E47D2503D7 CRC64;
MVAAQKLKVT ICGAGRTGHL AAVLFSQKSD IEVTLLSSQH VMPASYQKNG AQIRAFLPDG
AVLAASPCCV TACPYEACSD ADVVIITVPS HARDGVLKRI QPALPRNKPV FVGAIPGFGG
FDWLAEDLLG ALSNVVLWGM KDVPHIAFDL TLGESVRLGG AKSHLYVALH RRETPAMAGI
LLNYLSRLYD SPLMLLEDYL EITLTPGNPI MHGSVIYGLI GPWGQWHHHP FNHVPCWWND
CPELGAYFLA RCDAENQALC KAAEAVLEID LSSVQPLQQE IMDAYGDLIA NPRTLLSVLR
TNQAYAGIPL PLIRAENSEG YVFDRRHRVF QEDIAFGLGL LVAIGERLKV PVPCMKEIYL
WCSQFMGEVA PHVPLPVTWP EIKVAQECG
//
