ID W0RF46_9BACT Unreviewed; 670 AA.
AC W0RF46;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:AHG88960.1};
GN ORFNames=J421_1423 {ECO:0000313|EMBL:AHG88960.1};
OS Gemmatirosa kalamazoonensis.
OC Bacteria; Gemmatimonadota; Gemmatimonadetes; Gemmatimonadales;
OC Gemmatimonadaceae; Gemmatirosa.
OX NCBI_TaxID=861299 {ECO:0000313|EMBL:AHG88960.1, ECO:0000313|Proteomes:UP000019151};
RN [1] {ECO:0000313|EMBL:AHG88960.1, ECO:0000313|Proteomes:UP000019151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KBS708 {ECO:0000313|EMBL:AHG88960.1,
RC ECO:0000313|Proteomes:UP000019151};
RX PubMed=24699952;
RA Debruyn J.M., Radosevich M., Wommack K.E., Polson S.W., Hauser L.J.,
RA Fawaz M.N., Korlach J., Tsai Y.C.;
RT "Genome Sequence and Methylome of Soil Bacterium Gemmatirosa
RT kalamazoonensis KBS708T, a Member of the Rarely Cultivated Gemmatimonadetes
RT Phylum.";
RL Genome Announc. 2:e00226-14(2014).
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DR EMBL; CP007128; AHG88960.1; -; Genomic_DNA.
DR AlphaFoldDB; W0RF46; -.
DR STRING; 861299.J421_1423; -.
DR KEGG; gba:J421_1423; -.
DR PATRIC; fig|861299.3.peg.1446; -.
DR eggNOG; COG1964; Bacteria.
DR HOGENOM; CLU_409789_0_0_0; -.
DR InParanoid; W0RF46; -.
DR Proteomes; UP000019151; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR034474; Methyltransferase_Class_D.
DR InterPro; IPR007197; rSAM.
DR PANTHER; PTHR43306; 7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43306:SF1; 7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000019151};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 105..321
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT REGION 519..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..610
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 670 AA; 73153 MW; 8A33A89F4AEF6E12 CRC64;
MPGMGLRGDR ILRYVAAFCP QCHAEEPGRP LAEVPRLGGY LAERDGRVWL ERGCARHGRI
TTLYDEDPEI LAYLEQWTAP TKTHTPDVAG NFDPVPSAYL RGLGEMQTQH TCILLEDVAA
TCNLTCPTCF AGSSPHTHGF VPVAEVLDNV DQRLARENGR IDVLMLSGGE PTLHPELARL
LDALVERDVV RILLNTNGVK IATSDATLRL LERHNTRVEV YLQHDGFRRE THLAHRGADL
RRIKADAVRR LSDAGVFTTL TMTAASGVND DEIGSVIALA LDTPFVGGVS IQPQFGSGRS
TPIDPTRRLT HGGVLRRLGP QTGGMVTWRD LTALPCSHPH CCSVGYMIRT DGGAWKSLVG
MIGHDRLKQH LGLVANRIND PELSADLRAL LQHSLLNLLS EQSSLTHPTV AQLFRDVCES
CDLGLSTLLR LAGESLLGRR AAFRRLVSER VKRITVKPFM DVHTMLEERL LQCCVHVGTV
GTVGTRDSGL GTRPPRVPRP ESRLSRLSRV PCINARRSAR CRHGRRSARR SSRSGHGPWR
RTAHHIVRLR VVWVPTLEEL SSVRSRERAA AGGGAGSGAL LRHDDRGAAR VGVRPTGRGD
RDERPRTVGV PARDPRGAHG NAVQAEAAGA RARLPRAGTR VGRRGTRATV VSAAAGLFAA
QRVTVTTTRR
//
