ID W0SDT5_9PROT Unreviewed; 653 AA.
AC W0SDT5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Alpha-subunit of fatty acid oxidation complex {ECO:0000313|EMBL:BAO27893.1};
GN ORFNames=SUTH_00073 {ECO:0000313|EMBL:BAO27893.1};
OS Sulfuritalea hydrogenivorans sk43H.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Sterolibacteriaceae; Sulfuritalea.
OX NCBI_TaxID=1223802 {ECO:0000313|EMBL:BAO27893.1, ECO:0000313|Proteomes:UP000031637};
RN [1] {ECO:0000313|EMBL:BAO27893.1, ECO:0000313|Proteomes:UP000031637}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM22779 {ECO:0000313|EMBL:BAO27893.1};
RX PubMed=25017294; DOI=10.1016/j.syapm.2014.05.010;
RA Watanabe T., Kojima H., Fukui M.;
RT "Complete genomes of freshwater sulfur oxidizers Sulfuricella denitrificans
RT skB26 and Sulfuritalea hydrogenivorans sk43H: genetic insights into the
RT sulfur oxidation pathway of betaproteobacteria.";
RL Syst. Appl. Microbiol. 37:387-395(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
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DR EMBL; AP012547; BAO27893.1; -; Genomic_DNA.
DR RefSeq; WP_041096201.1; NZ_AP012547.1.
DR AlphaFoldDB; W0SDT5; -.
DR STRING; 1223802.SUTH_00073; -.
DR KEGG; shd:SUTH_00073; -.
DR HOGENOM; CLU_009834_16_1_4; -.
DR OrthoDB; 5287258at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000031637; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000031637}.
FT DOMAIN 314..488
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 491..580
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 653 AA; 69831 MW; C6E2E3FF9C812DE1 CRC64;
MSNFKHWRLE READDSGVAW AILDTADSST NTLGADVMAE LGLILDECAK HPPKGLIFTS
AKEAGFIAGA NIEEFVASDT PEKALALVKR GWDLYNRLAA VSYPTLALVR GHCMGGGTEL
ALACRYRIAV DEPGTRFALP EVMLGIVPGW GGMLRLPQIV GPAAAFDMML TGKNIDAKRA
KKMGLADECL PPRVMENAAR MLVLSGKPMR QSQLLLMQRL MNGPLKGFVA SGAKKQVAKR
ARREHYPAPY AIIDQWQNHG GNTLAVPAGA PISLDALVTH PTTRNLIRVF FLQDRLKGFG
KLSGQTGKDF APRHVHVVGA GVMGGDIAAW CALRGMTVTL QDQSVERIAP AVGRAAKFFE
KKLRDRKLAR FALDRLIADP RGDGVRQADV IIEAIFENLE AKQALFADIE ARAKPEALLA
SNTSSLKLAD IAAKFKDPSR LVGIHFFNPV AMMPLVEVVA GAGTAPEAAQ KAAAFVRKID
KLPLPVKDAP GFLVNAVLAP YMNEAMKCVD EGIAPETIDA AMLAFGMPMG PIELADTVGL
DVAVAAGRQL VGDANPPQKL VELVEGKKLG KKSGQGFYTW IDGKAQKSKV GAGDTANQAL
AQRLITPLLD ATQRLVKDGV VADAELADAG VIFGTGFAPY TGGPMNYLQT HRA
//
