ID   W0T9M5_KLUMD            Unreviewed;       866 AA.
AC   W0T9M5;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=Nitrogen permease regulator 3 {ECO:0000256|RuleBase:RU368069};
DE   AltName: Full=Required for meiotic nuclear division protein 11 {ECO:0000256|RuleBase:RU368069};
GN   Name=NPR3 {ECO:0000313|EMBL:BAO40125.1};
GN   ORFNames=KLMA_40101 {ECO:0000313|EMBL:BAO40125.1};
OS   Kluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275)
OS   (Yeast) (Candida kefyr).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=1003335 {ECO:0000313|EMBL:BAO40125.1, ECO:0000313|Proteomes:UP000065495};
RN   [1] {ECO:0000313|EMBL:BAO40125.1, ECO:0000313|Proteomes:UP000065495}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DMKU3-1042 / BCC 29191 / NBRC 104275
RC   {ECO:0000313|Proteomes:UP000065495};
RX   PubMed=25834639; DOI=10.1186/s13068-015-0227-x;
RA   Lertwattanasakul N., Kosaka T., Hosoyama A., Suzuki Y., Rodrussamee N.,
RA   Matsutani M., Murata M., Fujimoto N., Suprayogi, Tsuchikane K., Limtong S.,
RA   Fujita N., Yamada M.;
RT   "Genetic basis of the highly efficient yeast Kluyveromyces marxianus:
RT   complete genome sequence and transcriptome analyses.";
RL   Biotechnol. Biofuels 8:47-47(2015).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division.
CC       {ECO:0000256|RuleBase:RU368069}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000256|RuleBase:RU368069};
CC       Peripheral membrane protein {ECO:0000256|RuleBase:RU368069}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC       ECO:0000256|RuleBase:RU368069}.
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DR   EMBL; AP012216; BAO40125.1; -; Genomic_DNA.
DR   AlphaFoldDB; W0T9M5; -.
DR   VEuPathDB; FungiDB:KLMA_40101; -.
DR   OrthoDB; 1381214at2759; -.
DR   Proteomes; UP000065495; Chromosome 4.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-UniRule.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR   PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Meiosis {ECO:0000256|RuleBase:RU368069};
KW   Signal {ECO:0000256|RuleBase:RU368069}.
FT   REGION          41..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          273..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        273..288
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        289..322
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   866 AA;  98592 MW;  FF42A16983B0CE48 CRC64;
     MHTNLPDSCL IGIALTVSTH SGPQLVYHYP PINYAAATNS KKDHHLNKKK HHYSLDQEEE
     EAASDSSSSS DDYSSGLSDS ELSTDYADTS SSDSDSSSSS LDHHVHSPSL DSQHGSTTNM
     DESNNGRNNS VNISTAASVS NSGMLRSRQS QISANKLFQL LNNGNNNNNN STSLTNASGS
     LRDSLYSGFT DPYHHELDQD LDPELQQLVQ ELLDDSMFQR DAFQDVSKVL NFNAEFVAEL
     CCPRKEMCNT RFEFTVDDLC FLGLPIHADA KGRWKKAKKR KHSSKKSATV KSSGRNRSNT
     EDSTNKNQRQ QQQQQQDQPT TESDDESGQE GETSKSEMLN EMYAANEEEF ESLEKSINMF
     QVCFIMNPQI IEYNERVDDM YHFVVTRLSL ILRYIQGKNG YVTKECANII KCRDQVTKHS
     PIYKSLKSPW RKGKFLYERI LYQSSLARAL TKCFNCIKNN QIANLEIDRD KIVSLQIPIK
     TEFSVLPNLK EDPVIRGSYL SSILNESFLG GSLSGGIAED SENIYANHER MLDFGLLLLD
     EPENIVKGLE NASFDNGITD LLLINLVRQL KPTYRLFQYK ALIKELLDSN DDSNYNDEFL
     ETTLKSLCLH LIYWRHARLI LPLSPRYTYI VSPLAPISGF SNEDYAHAEY DTVFKKQNTL
     TSNTDDISLI YQNKKSFSDK FPSLPSLPSF LQLISTQKPK PFGHIIPSNE HKAMYLNALA
     WLMRYGYLTQ LLTFVYIRVD KRIKIAVDED LERDGIRSNK KGRSDNFVSG GENYNGSDFD
     DLEMLNDNDF TIILEPERNT ALEKRWLFKC AEALPPDLQV LFKQAVKYFN GKIPLEYVMI
     KENIPKHEMK RLLQALGNYV VEVKHW
//