ID W0T9P6_KLUMD Unreviewed; 613 AA.
AC W0T9P6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Translation initiation factor eIF2B subunit delta {ECO:0000256|ARBA:ARBA00044147};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit delta {ECO:0000256|ARBA:ARBA00044356};
GN Name=GCD2 {ECO:0000313|EMBL:BAO38794.1};
GN ORFNames=KLMA_20336 {ECO:0000313|EMBL:BAO38794.1};
OS Kluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275)
OS (Yeast) (Candida kefyr).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=1003335 {ECO:0000313|EMBL:BAO38794.1, ECO:0000313|Proteomes:UP000065495};
RN [1] {ECO:0000313|EMBL:BAO38794.1, ECO:0000313|Proteomes:UP000065495}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DMKU3-1042 / BCC 29191 / NBRC 104275
RC {ECO:0000313|Proteomes:UP000065495};
RX PubMed=25834639; DOI=10.1186/s13068-015-0227-x;
RA Lertwattanasakul N., Kosaka T., Hosoyama A., Suzuki Y., Rodrussamee N.,
RA Matsutani M., Murata M., Fujimoto N., Suprayogi, Tsuchikane K., Limtong S.,
RA Fujita N., Yamada M.;
RT "Genetic basis of the highly efficient yeast Kluyveromyces marxianus:
RT complete genome sequence and transcriptome analyses.";
RL Biotechnol. Biofuels 8:47-47(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR EMBL; AP012214; BAO38794.1; -; Genomic_DNA.
DR AlphaFoldDB; W0T9P6; -.
DR VEuPathDB; FungiDB:KLMA_20336; -.
DR OrthoDB; 169924at2759; -.
DR Proteomes; UP000065495; Chromosome 2.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR InterPro; IPR000649; IF-2B-related.
DR InterPro; IPR042529; IF_2B-like_C.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR10233; TRANSLATION INITIATION FACTOR EIF-2B; 1.
DR PANTHER; PTHR10233:SF14; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA; 1.
DR Pfam; PF01008; IF-2B; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:BAO38794.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 613 AA; 67369 MW; 11CF54691ED037C3 CRC64;
MSEGAVESKE PKEPVKVETN AEKAVNQKTT VSSTSGKALT NKELKELKKK EKAAKRAANK
QSIGISLEKQ QQQAAAKREK KQQQRELLAA KKNKSVEVVK HNDKKSTLFG HLETTEERRT
SLLALLSVIT SLGASKITAM GLVLPMLSTT LAAASSQPTS GSQLSAGLSG SNTNLQSLAH
SEDYEAQQML NSLSLDESST LVPGTSSIIP NTIASQFTSQ QSLASVKELI ANRDMLHPAI
SSLTLDYALY KIIGSIPRCI AMMEAFEAVI KDYKTPEGTT LSRNLTSYLS HQIDFLKKSR
PLSVTMGNAI RWLKQEISLI DPSTSDSKAK EELCDKIALF AREKVELADQ LIIETASQHI
EEGSTILTYG CSKVLTDLFL HNAINLGKKF QIVIVDSRPL FEGRKMAESL KNHGLDVLYV
PITALGTVFN MDIKYVFLGA HSILSNGFLY SRVGTAQIAM LANRRNIPVL VCCESLKFSQ
RVQLDSVTSN ELADPNDLVI IDSANPVQRH SNQGFLLQQF IKERESVQKE VENNTKQKNK
SGSGSANTES VDDTKSNKHK PILADWEKQP NLNIFNIMYD LTPPDYIKKI ITEFGSLPPS
SVPVVLREYK GSA
//
