ID W0T9Z7_KLUMD Unreviewed; 731 AA.
AC W0T9Z7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN Name=ERG7 {ECO:0000313|EMBL:BAO39636.1};
GN ORFNames=KLMA_30341 {ECO:0000313|EMBL:BAO39636.1};
OS Kluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275)
OS (Yeast) (Candida kefyr).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=1003335 {ECO:0000313|EMBL:BAO39636.1, ECO:0000313|Proteomes:UP000065495};
RN [1] {ECO:0000313|EMBL:BAO39636.1, ECO:0000313|Proteomes:UP000065495}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DMKU3-1042 / BCC 29191 / NBRC 104275
RC {ECO:0000313|Proteomes:UP000065495};
RX PubMed=25834639; DOI=10.1186/s13068-015-0227-x;
RA Lertwattanasakul N., Kosaka T., Hosoyama A., Suzuki Y., Rodrussamee N.,
RA Matsutani M., Murata M., Fujimoto N., Suprayogi, Tsuchikane K., Limtong S.,
RA Fujita N., Yamada M.;
RT "Genetic basis of the highly efficient yeast Kluyveromyces marxianus:
RT complete genome sequence and transcriptome analyses.";
RL Biotechnol. Biofuels 8:47-47(2015).
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR EMBL; AP012215; BAO39636.1; -; Genomic_DNA.
DR AlphaFoldDB; W0T9Z7; -.
DR VEuPathDB; FungiDB:KLMA_30341; -.
DR OrthoDB; 2712461at2759; -.
DR Proteomes; UP000065495; Chromosome 3.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR Gene3D; 6.20.120.20; -; 1.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362003};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 98..344
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 389..723
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 731 AA; 84062 MW; 0D8EE59C72EEAC13 CRC64;
MLELYSEKIK LPRTDPTRWR LHTDELGRET WEYLSVEESK KIPQSTFAQW LLQCEEFPEP
QPQVNSKTSN FTAWNAAHNG AKFFELLQDP NSGIFPCQYK GPMFMTIGYV VTMYLAKLEI
PEHERIELIR YIANYAHPVD GGWGLHTTDK STVLGTVLNY VSLRLLGLPK DHEVCTRARD
TLHRLGGAIG SPHWAKIWLS ILNLYKWEGV NPAPPELWMF PYSLPIHPAR WWVHTRGIYL
PVSYLSSTRY TCDLDPLLKE IRSEIYTKPF ETINFAEHRN TVCGVDLYYP HTKVLNTVNA
MMTCYEKYIR PNWMLKKATK RVHELVKKEI ANTDYLCIAP VNMAFCAIVT LIEEGKDSTE
FNSFLYRFKD VLFHGPQGLT VMGTNGVQVW DCAFFVQYMF TAGLAELPEF HDSVSRSFKF
LCRSQFTENC ADGSFRDKRL GAWPFSTKTQ GYTVSDCTAE AIKAIIMVLN SASFKDVHDY
YDPKKLNNGI DVLLSLQNVS SFEYGSFSTY EKIKATTLLE KLNPAEVFGN IMVEYPYVEC
TDSSVLGLTY FRKHFDYRKK DIDFAIKEAI AYIKNVQNED GSWYGCWGIC YTYAGMFALE
ALYTVGENYE NSEVVRKGCD FLVSKQLPDG GWSETMKSSE LHSYVSDKTS YVVQTAWAII
GLILAKYPNK HVIDRGIKLL KERQQPSGEW KFEAVEGVFN HSCAIEYPSY RFLFPIKALG
LYVKEYKDNA I
//
