ID W0TBH4_KLUMD Unreviewed; 915 AA.
AC W0TBH4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Sulfate permease 2 {ECO:0000313|EMBL:BAO40171.1};
GN Name=SUL2 {ECO:0000313|EMBL:BAO40171.1};
GN ORFNames=KLMA_40147 {ECO:0000313|EMBL:BAO40171.1};
OS Kluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275)
OS (Yeast) (Candida kefyr).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=1003335 {ECO:0000313|EMBL:BAO40171.1, ECO:0000313|Proteomes:UP000065495};
RN [1] {ECO:0000313|EMBL:BAO40171.1, ECO:0000313|Proteomes:UP000065495}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DMKU3-1042 / BCC 29191 / NBRC 104275
RC {ECO:0000313|Proteomes:UP000065495};
RX PubMed=25834639; DOI=10.1186/s13068-015-0227-x;
RA Lertwattanasakul N., Kosaka T., Hosoyama A., Suzuki Y., Rodrussamee N.,
RA Matsutani M., Murata M., Fujimoto N., Suprayogi, Tsuchikane K., Limtong S.,
RA Fujita N., Yamada M.;
RT "Genetic basis of the highly efficient yeast Kluyveromyces marxianus:
RT complete genome sequence and transcriptome analyses.";
RL Biotechnol. Biofuels 8:47-47(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|ARBA:ARBA00008692, ECO:0000256|RuleBase:RU362052}.
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DR EMBL; AP012216; BAO40171.1; -; Genomic_DNA.
DR AlphaFoldDB; W0TBH4; -.
DR VEuPathDB; FungiDB:KLMA_40147; -.
DR OrthoDB; 1082533at2759; -.
DR Proteomes; UP000065495; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF55; SODIUM-INDEPENDENT SULFATE ANION TRANSPORTER; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 272..295
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 332..353
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 374..398
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 471..490
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 511..531
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 555..577
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 584..601
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 801..855
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 915 AA; 101820 MW; 80ACD4BC6325C3C2 CRC64;
MVSHQLVSDR GKNYDSVDGD SINKYSDESP DFDQLEQEYD DLKTSEIIAP HISNGHSIGS
SPRHHHLYDD MHLDSIVDTT YQDEESILKG TSTGKTGIED VTVRNIYTYD SLQVPNYEEP
IVNLKDAYDE KIKPYVRLQS VTDYLLSLFP LLKWIHHYNL SWLYNDVVAG ITVGCVLVPQ
SMSYAQIASL PPQYGLYSSF VGAFIYSFFA TSKDVCIGPV AVMSLETAKV IARVTKKVGD
SNPEITAPII ATTLSLICGA IALGVGLLRL GFLVEFISLN AVAGFMTGSA INIVAGQVPA
LMGYGKAVNT RAATYKVIIN SLKHLPDTKL DAVFGLIPLV ILYVWKYFCG TLGPKLVDRY
VTRRDPKRAS IYKLVLFYAQ ALRNAFVIIL FTLISWGITR HKKKKDYPIS VLGKVPSGLK
HVGVMKLPDG LVSHLGSELP SAVIILVLEH IAISKSFGRV NDYKVVPDQE LIAIGVTNLI
STFFNAYPAT GSFSRSALKA KCNVKTPLSG LFTGSCVLLA LYCLTGAFYY IPKACLSAVI
IHAVSDLVAS YKTTWNFYLM NPLDFVCFLV TVLITIFSSI ENGIYFAMCW SAAMLLLKVV
FPTGQFLGYV ELCEVTNAEV NKSIDRIIIA EPSKDGSSDD NTTDSNGKPV ENVKIQVNSN
KLTDQESTTG AAAAAGNLNH AHLQYHVKWM PLDNNYQHEL NPEVVVHPPP PGVIVYRPTE
SWTYVNCSRQ YDKIFARVKE LTRPGKSARH VRKVDRVWND PGEWEPPYLL RKLFKFKKSD
SSSADLEGRQ VQDSRPILKV LAMDWSQVNQ IDSTGIQNLV DLRKAINKYA NRQVEFHFSG
IISPWIKRGL VNAGFGTINE EFSDESLLVG HTSYNLVKSR GEHEDEEQTV ALYTANGVNL
PFFHIDMPDF HKWHL
//
