ID W0TC11_KLUMD Unreviewed; 1734 AA.
AC W0TC11;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=rRNA biogenesis protein RRP5 {ECO:0000313|EMBL:BAO40945.1};
GN Name=RRP5 {ECO:0000313|EMBL:BAO40945.1};
GN ORFNames=KLMA_50291 {ECO:0000313|EMBL:BAO40945.1};
OS Kluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275)
OS (Yeast) (Candida kefyr).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=1003335 {ECO:0000313|EMBL:BAO40945.1, ECO:0000313|Proteomes:UP000065495};
RN [1] {ECO:0000313|EMBL:BAO40945.1, ECO:0000313|Proteomes:UP000065495}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DMKU3-1042 / BCC 29191 / NBRC 104275
RC {ECO:0000313|Proteomes:UP000065495};
RX PubMed=25834639; DOI=10.1186/s13068-015-0227-x;
RA Lertwattanasakul N., Kosaka T., Hosoyama A., Suzuki Y., Rodrussamee N.,
RA Matsutani M., Murata M., Fujimoto N., Suprayogi, Tsuchikane K., Limtong S.,
RA Fujita N., Yamada M.;
RT "Genetic basis of the highly efficient yeast Kluyveromyces marxianus:
RT complete genome sequence and transcriptome analyses.";
RL Biotechnol. Biofuels 8:47-47(2015).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR EMBL; AP012217; BAO40945.1; -; Genomic_DNA.
DR VEuPathDB; FungiDB:KLMA_50291; -.
DR OrthoDB; 167902at2759; -.
DR Proteomes; UP000065495; Chromosome 5.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR CDD; cd00164; S1_like; 1.
DR CDD; cd05702; S1_Rrp5_repeat_hs11_sc8; 1.
DR CDD; cd05703; S1_Rrp5_repeat_hs12_sc9; 1.
DR CDD; cd05693; S1_Rrp5_repeat_hs1_sc1; 1.
DR CDD; cd05698; S1_Rrp5_repeat_hs6_sc5; 1.
DR CDD; cd05706; S1_Rrp5_repeat_sc10; 1.
DR CDD; cd05708; S1_Rrp5_repeat_sc12; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 9.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR045209; Rrp5.
DR InterPro; IPR048058; Rrp5_S1_rpt_hs11_sc8.
DR InterPro; IPR048059; Rrp5_S1_rpt_hs1_sc1.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR23270; PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5; 1.
DR PANTHER; PTHR23270:SF10; PROTEIN RRP5 HOMOLOG; 1.
DR Pfam; PF00575; S1; 4.
DR SMART; SM00386; HAT; 5.
DR SMART; SM00316; S1; 12.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 11.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50126; S1; 10.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 117..230
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 499..569
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 594..665
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 685..758
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 783..852
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 883..959
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 990..1062
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1075..1146
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1164..1232
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1252..1323
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1331..1406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1426..1449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..182
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1337..1357
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1734 AA; 193918 MW; 2A4023B8257B3068 CRC64;
MVAQQSKRKR DEESPLTRQD ATEAPSKSAL SKSDEISFPR GGSSALSPLE VKQVANEVVA
DVLFGKDDAA TGSEQPKKKR KNSKKGTALE GTELDNEDKE DKTDLVEHFG MKQMNKDTIL
LGQIQSISKH ELKVSLLDGL HGYVSLTDIS EQMNKTLEKL DEDMESENED SDSEYDSSDD
EDESNALASK ELPDLSNYFK VGQWLRCIVH ENTSSTEVKK GKKKLELSIE PSLVNKFDED
DLTKHCVVQC AVKSIEDHGL MLDIGLDNLT GFISKKDLPD FKSILPGAVF LANVNKRSGR
TVNVNLDLGG KSTKTDKISS IDAILPGQTI DFVPQTITNH GIIGKAFGLI VAFLPLPHSN
CFTVEELKQK YAIGNVINAR ILATTVMKSG NKVAVVSTQP HINALTPKLQ EIEALESFPV
GYIFDSCTYK GRDSQFFYVS INDEQVGQIH ISKAGETEPT GSVRARVLGY NNVDKLYSLT
SDPAQLEVKY LRATDIPIGE LLSNCEVVTV SEKGIELKIF NGQFKAFVPP LHISDTRLVY
PERKFKIGSK VKGRILNIDS VGRITVTLKK SIVNADEDVL KLVYSEDDVV KVENEELRTI
ATVELFKPNG CLVSFFNNIK AFIPNKEISE AFVKKPQEHL RLGQTVIVKI LNHDFQRNRI
IATCKISAES SSKQKEAIES LIVGRSIIDA IVIEKSKDSA VVEAKESGLR GVVYTGHLSD
DRIEQNRASL KKLKIGSEIR GLVLDKDTRT RVFNMSCKKS LISDAENGTL PLTYSDIKSK
EKTTPMHGYV KSISDRGVFV AFNGKFVGLV LPSYAAETRD IDINKKYYVN QTVTVYLLRT
DDEHERFLLT ILKPKEEKTQ GTSSNLMNPV DKSVKNMSDF TIGKVTKATI ISVKRNQLNV
ALADNVHGRI SISEVFDKFE DIKNQKAPLS VFKKDDIIKV KIIGFHDIKS RKFLPISHTN
SKSHLVELSA KPSALNSPLS EKTLKDFTAE QTVLGFINNY SKETAWLTIT PTVKAKLPIF
EISDQGNDFS LPIDEKYPIG TALKVTVKSI DTEHDSLIVT ARSHNISSIN EIKEGDVLPA
RVISVQDTYV LLSLGKDVTG VSFITDALDD YSQSLKDVYD SKKKSIVSAT VLNVDIANKK
INLSLRSASP KDRSIKSSEE LKRGDVVRGF VKSITDKGLF ISLSSTLQAF VPVSKLTDAF
IKEWKKFYNR GQSVVGKVVN CDDDKHILLT MKESEVNGEL NVLKTYSEIN VGDIFQGSVK
NVTEFGVFIK LDGTVNVTGL AHKTEVADAK IENLENLFGE GDKVKAIVLK TNPEKKQISL
GLKASYFTKN DSSAVSEQEE VEEENDSEME VDNEDEEAVA PSEKQSDITV SKKTDDDDEI
MDDVQFDYSD VEDKEDRANS NKNVMSTDGL SLSTAFDWTG SILDQAQDEE ESSDEEDFIQ
SKKQKKKRAN QVQDKTIDIN TRIPESVGDF ERLIMGNPNS SVVWMNYMAF HLQLSEVEKA
REIVERALKT INFREEAEKL NIWIASLNLE NTFGTEETLE DVFNRACQYM DSFVMHMKLL
SIYQMSQKNE KAKELFKVTA KKFGSEKVSV WVAWGGFLID IQEIDEAHEV LGKALKALPK
RNHIEVVKKF AQLEFSKGDP EQGRSLFEGL IADAPKRVDL WNVYIDQEIK ANEKSKVEDL
FERVVTKKIT RKQAKFFFNK WLQFEEQKDD QKQVDYVKAK AAEYVAKHKS SQEE
//
