ID   W0TC21_KLUMD            Unreviewed;      1216 AA.
AC   W0TC21;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Imitation switch two complex protein 1 {ECO:0000313|EMBL:BAO40578.1};
GN   Name=ITC1 {ECO:0000313|EMBL:BAO40578.1};
GN   ORFNames=KLMA_40554 {ECO:0000313|EMBL:BAO40578.1};
OS   Kluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275)
OS   (Yeast) (Candida kefyr).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=1003335 {ECO:0000313|EMBL:BAO40578.1, ECO:0000313|Proteomes:UP000065495};
RN   [1] {ECO:0000313|EMBL:BAO40578.1, ECO:0000313|Proteomes:UP000065495}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DMKU3-1042 / BCC 29191 / NBRC 104275
RC   {ECO:0000313|Proteomes:UP000065495};
RX   PubMed=25834639; DOI=10.1186/s13068-015-0227-x;
RA   Lertwattanasakul N., Kosaka T., Hosoyama A., Suzuki Y., Rodrussamee N.,
RA   Matsutani M., Murata M., Fujimoto N., Suprayogi, Tsuchikane K., Limtong S.,
RA   Fujita N., Yamada M.;
RT   "Genetic basis of the highly efficient yeast Kluyveromyces marxianus:
RT   complete genome sequence and transcriptome analyses.";
RL   Biotechnol. Biofuels 8:47-47(2015).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00475}.
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DR   EMBL; AP012216; BAO40578.1; -; Genomic_DNA.
DR   AlphaFoldDB; W0TC21; -.
DR   VEuPathDB; FungiDB:KLMA_40554; -.
DR   OrthoDB; 1382023at2759; -.
DR   Proteomes; UP000065495; Chromosome 4.
DR   GO; GO:0000785; C:chromatin; IEA:UniProt.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018501; DDT_dom.
DR   InterPro; IPR028941; WHIM2_dom.
DR   InterPro; IPR013136; WSTF_Acf1_Cbp146.
DR   PANTHER; PTHR32075; ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED; 1.
DR   PANTHER; PTHR32075:SF6; ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED; 1.
DR   Pfam; PF02791; DDT; 1.
DR   Pfam; PF10537; WAC_Acf1_DNA_bd; 1.
DR   Pfam; PF15613; WSD; 1.
DR   PROSITE; PS50827; DDT; 1.
DR   PROSITE; PS51136; WAC; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00475}.
FT   DOMAIN          23..130
FT                   /note="WAC"
FT                   /evidence="ECO:0000259|PROSITE:PS51136"
FT   DOMAIN          396..456
FT                   /note="DDT"
FT                   /evidence="ECO:0000259|PROSITE:PS50827"
FT   REGION          276..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          532..589
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          742..772
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1171..1216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1046..1073
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        276..300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..327
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        532..548
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        549..578
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        745..772
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1186..1209
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1216 AA;  140838 MW;  B3B331B13552FEF2 CRC64;
     MVLYKRKSIT LPEARPLPSN INRKIWYIKE TGEWFLTYAE FLERLDFYMR HYFTCEITGA
     SCLTFFEALN SEEEQFQYVE KMFPLKLREP VAKFIHFNEI RRLDMLVEQV YSNFKNNFFP
     GETVYLRKAK QEVASGDEDP EKQLRLQLQQ MQQQPTSPQN SSQSNVYIIK EKAQFNAVID
     RNTGQELVPA HTKYMLQEAY GSASIIADED QIYRDRSTFT KHLIKCFCKI TLRRASSKMG
     APWCVKDEYL PIYNLSPEWP PHMLKYREDY VDMQYLQQQQ QQQQQQQATD SNNRSGYTTA
     DSADLKRELD AARTATPDHK RLKTEDSVME YSPSVDHGNL ESNNNVQNDH QTITEITEDL
     KIPFSAPRPA SISNKLFSYS KEYVALPAAS NDKSFSDSVG KLLHCYQFLM GFHTTLQLSK
     FSWDNFVNSM RFTDRRNLMD EFVDISLEDG TKNKVERFNA WNSLVYDYID SLNSDKMRIT
     VELDEDINED YLDEIKITGA SLTVECFCSL LRLFMDTDGN WTTLVTSEWL EGEDLDEELE
     EDKEDGVDED SNGNDKDDGV NPNEDDSESG KNENKSANDD NDDDNDDESK LETALEKCLN
     YRKMEWTDRL AKRQFSNGHW LIILLGVLQD CMHLPMYTTT IKNFMKKLIP FENSTSNIAL
     NKQLWRQFCK NISIKEKIDI MWILVEVLSN YSSIIRSAMD DSMELSNQIR SERFRLSRDL
     KACANTVSEL KESIYLMSVE NGGVNGNEKE EEKEEEGEKE KEKEKEKELA ERQEKLRKAN
     TELERLQKRK HFLDVKLIES DIQRLKPLGS DRYGNKIYWL EYSGVPRPDS FSTEKHILSN
     RLWIQGPVKE VALLYFNLSE DQYENWISIS RTSGKAEATK QIFNVYRDDS GSYYHHDEQG
     DVMLINDEGV VNSYIELSPL QRKIIDETPE NLLLSPNDWV FLQDTNELTN YMEWLDSWGK
     REHETLKQLE YVIEPLKENL LDYQKLVNQK LEQERNSIVA EINAINITEE EFSAGSSVAN
     TTGTHIDDEL EDIANQIMAL DDASKTRKVL LQIQDLEAKR DKLLEKKKTA VETADSSEGS
     GSGSKISAVE RKKILASREK KIGNLKDALD KLINLQRESE RISITEWSNE MAIDVWSNEL
     FKCNGNVKSA KDPPVITVSE KIAKILEQAS IIEDQPSISS TESEEQTQTQ DEHKTQDVTP
     HDQSDKSDVS RKNTQA
//