ID W0TC51_KLUMD Unreviewed; 846 AA.
AC W0TC51;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Protein SYG1 {ECO:0000313|EMBL:BAO40361.1};
GN Name=SYG1 {ECO:0000313|EMBL:BAO40361.1};
GN ORFNames=KLMA_40337 {ECO:0000313|EMBL:BAO40361.1};
OS Kluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275)
OS (Yeast) (Candida kefyr).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=1003335 {ECO:0000313|EMBL:BAO40361.1, ECO:0000313|Proteomes:UP000065495};
RN [1] {ECO:0000313|EMBL:BAO40361.1, ECO:0000313|Proteomes:UP000065495}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DMKU3-1042 / BCC 29191 / NBRC 104275
RC {ECO:0000313|Proteomes:UP000065495};
RX PubMed=25834639; DOI=10.1186/s13068-015-0227-x;
RA Lertwattanasakul N., Kosaka T., Hosoyama A., Suzuki Y., Rodrussamee N.,
RA Matsutani M., Murata M., Fujimoto N., Suprayogi, Tsuchikane K., Limtong S.,
RA Fujita N., Yamada M.;
RT "Genetic basis of the highly efficient yeast Kluyveromyces marxianus:
RT complete genome sequence and transcriptome analyses.";
RL Biotechnol. Biofuels 8:47-47(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC {ECO:0000256|ARBA:ARBA00009665}.
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DR EMBL; AP012216; BAO40361.1; -; Genomic_DNA.
DR AlphaFoldDB; W0TC51; -.
DR VEuPathDB; FungiDB:KLMA_40337; -.
DR OrthoDB; 7162at2759; -.
DR Proteomes; UP000065495; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd14475; SPX_SYG1_like; 1.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR10783:SF103; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1; 1.
DR PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 2.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 347..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 466..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 558..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 678..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..244
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT DOMAIN 552..762
FT /note="EXS"
FT /evidence="ECO:0000259|PROSITE:PS51380"
FT REGION 824..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 846 AA; 100293 MW; F0012871E18A956C CRC64;
MKFAEHLQES QVPEWSDKYI NYKLGKKKIK QFQKIRRMQD VGSMDNVMVR EFIHDWVIRD
QLKNCDEFYE WQLSKYQQKY LKLQRQIHMY VLETEKRGRL EDANRVTSEV SLSQLSESYG
SIFPGFSPVY LRYTLKQKIW HDLKQWLIVN DLYPSMPVAW KEKAPLLSKR TRRHGSRGQE
TFQSQPFQLP LSQIRRQLSE AILDFYLYLQ LLKNYRDLNV NGFRKIVKKF DKVLHQHQLR
GFMEYAKRNS TMFSHYDEYL KLIKDNIEHA DVVNANTFLG EGNNKEDLKK DPLTFFEQQS
INWYTMTLTS SSKDKKLNLE QIKSLSLQYS FNEQTVHRIN ASMSQMFLGS TLLGVSLTLV
ILMVVILARH STDRMKTNIL PIWSSFHYVT FMGLLFVIDC FVWYKVKINY RFIMFGEIHS
RNGPVLFNND FAMTHIPLQF FLATTFLCIC SLLAFCSLVM EKLEPWVLVW LLTGFILLFW
KFKAVQIWPY WDATWQARKY LIKTFIRLIF SGFFPVHFGD FFLGDIVCSL TYSMSQFATL
GCISFASSNE DKCRYENLLW IGILSCLPSY WRFVQCLRRY FDSYDWFPHL LNALKYAFSV
IFNASLYWYK SWPQDPKFRN LLIIFGCLNS SLTSMWDLIM DWSLLQKKSK HFLLRDDLYL
AGKKNWKTGE YDKFRTLIYY YFMLFDVIVR FEWVFYMVKN NTDYVRHPLV SLALATMEII
RRFNWVILRV ENEHVANVHL FKVTDDNWQL PFPVTEEGGE IAREDEYSAA AENMDNIALL
TAMRSNPESE TLPQPRAHSV SRAERRASVF EIIPWAHATD FQRPLEAPID ESAAASDSET
DSESLV
//
