ID W0TGE1_KLUMD Unreviewed; 432 AA.
AC W0TGE1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=26S protease regulatory subunit 6A {ECO:0000313|EMBL:BAO42712.1};
GN Name=RPT5 {ECO:0000313|EMBL:BAO42712.1};
GN ORFNames=KLMA_80401 {ECO:0000313|EMBL:BAO42712.1};
OS Kluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275)
OS (Yeast) (Candida kefyr).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=1003335 {ECO:0000313|EMBL:BAO42712.1, ECO:0000313|Proteomes:UP000065495};
RN [1] {ECO:0000313|EMBL:BAO42712.1, ECO:0000313|Proteomes:UP000065495}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DMKU3-1042 / BCC 29191 / NBRC 104275
RC {ECO:0000313|Proteomes:UP000065495};
RX PubMed=25834639; DOI=10.1186/s13068-015-0227-x;
RA Lertwattanasakul N., Kosaka T., Hosoyama A., Suzuki Y., Rodrussamee N.,
RA Matsutani M., Murata M., Fujimoto N., Suprayogi, Tsuchikane K., Limtong S.,
RA Fujita N., Yamada M.;
RT "Genetic basis of the highly efficient yeast Kluyveromyces marxianus:
RT complete genome sequence and transcriptome analyses.";
RL Biotechnol. Biofuels 8:47-47(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914, ECO:0000256|RuleBase:RU003651}.
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DR EMBL; AP012220; BAO42712.1; -; Genomic_DNA.
DR AlphaFoldDB; W0TGE1; -.
DR VEuPathDB; FungiDB:KLMA_80401; -.
DR OrthoDB; 1707207at2759; -.
DR Proteomes; UP000065495; Chromosome 8.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0010604; P:positive regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051173; P:positive regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0070682; P:proteasome regulatory particle assembly; IEA:UniProt.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:UniProt.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032501; Prot_ATP_ID_OB_2nd.
DR PANTHER; PTHR23073; 26S PROTEASOME REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR23073:SF7; 26S PROTEASOME REGULATORY SUBUNIT 6A; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF16450; Prot_ATP_ID_OB_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU003651};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:BAO42712.1};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003651};
KW Protease {ECO:0000313|EMBL:BAO42712.1};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942}.
FT DOMAIN 212..351
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 41..68
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 432 AA; 47950 MW; 8363A55D6BBBB36D CRC64;
MSTLEDLNNE SQLAEDDIDQ EFYNLSAADL TTRSKLLDNE IRIFRSELQR LSHENSQMLE
KIKDNQEKIK NNKQLPYLVA NVVEIMDMDE LQDSNEIDTQ GGNVNLDNAA KGKAAVIKTS
SRQTVFLPMV GLVDPVKLKP NDLVGVNKDS YLILDTLPSE FDSRVKAMEV DEKPTETYSD
VGGLDKQIEE LVEAIVLPMK QGEKFKDMGI KAPKGALMYG PPGTGKTLLA RACAAQTNAT
FLKLAAPQLV QMFIGEGAKL VRDAFALAKE KAPTIIFIDE LDAIGTKRFD SEKSGDREVQ
RTMLELLNQL DGFGSDDRVK VLAATNRVDV LDPALLRSGR LDRKIEFPLP TEDARAQILQ
IHSRKMTTDD SINWQELARS TDEFNGAQLK AVSVEAGMIA LRNGQSQVKH EDFVEAIGEV
QARKSKSVSF YA
//
