ID   W1DS32_KLEPN            Unreviewed;       319 AA.
AC   W1DS32;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Acetoin dehydrogenase E1 component alpha-subunit {ECO:0000313|EMBL:CDL12211.1};
DE            EC=1.2.4.- {ECO:0000313|EMBL:CDL12211.1};
OS   Klebsiella pneumoniae IS43.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=1432552 {ECO:0000313|EMBL:CDL12211.1, ECO:0000313|Proteomes:UP000019183};
RN   [1] {ECO:0000313|EMBL:CDL12211.1, ECO:0000313|Proteomes:UP000019183}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IS43 {ECO:0000313|EMBL:CDL12211.1,
RC   ECO:0000313|Proteomes:UP000019183};
RA   Barisic I., Mitteregger D., Hirschl A.M., Noehammer C., Wiesinger-Mayr H.;
RT   "Antibiotic resistance diversity of beta-lactamase producers in the General
RT   Hospital Vienna.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDL12211.1}.
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DR   EMBL; CBWK010000766; CDL12211.1; -; Genomic_DNA.
DR   AlphaFoldDB; W1DS32; -.
DR   eggNOG; COG1071; Bacteria.
DR   Proteomes; UP000019183; Unassembled WGS sequence.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CDL12211.1}.
FT   DOMAIN          12..308
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   319 AA;  34016 MW;  B9FF99466B6F47A4 CRC64;
     MLSKQALLQA YRKMREIRTF EERLHQENTS GDIPGFIHLY TGEEAIAVGV CENLTSADFI
     GSTHRGHGHC IAKGCDIHGM MAEIFGKDSG LCRGKGGSMH IADLSKGMLG ANAIVGGAPP
     LAIGAALTAK TLKTGNVGVS FTGDGGSNQG LVFEAINMAV VLQLPAVFIF ENNGYGEGTG
     HDYAVGGRDI ARRAAGFGLP AVTVDGTDFF AVYEATSEAV KRAREGGGPS VIEAKAFRWH
     GHFEGDPALY RAEGEVQRLR EQHDPLKIFT AKVKQHITQE ELAAIDEEVE ALVNDAVLKA
     RAAAYPAPED LLTDVYVSY
//