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Database: UniProt
Entry: W1H4A5_KLEPN
LinkDB: W1H4A5_KLEPN
Original site: W1H4A5_KLEPN 
ID   W1H4A5_KLEPN            Unreviewed;       373 AA.
AC   W1H4A5;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   03-JUL-2019, entry version 26.
DE   RecName: Full=T-protein {ECO:0000256|PIRNR:PIRNR001499};
OS   Klebsiella pneumoniae ISC21.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=1432558 {ECO:0000313|EMBL:CDL53724.1, ECO:0000313|Proteomes:UP000019189};
RN   [1] {ECO:0000313|EMBL:CDL53724.1, ECO:0000313|Proteomes:UP000019189}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISC21 {ECO:0000313|EMBL:CDL53724.1,
RC   ECO:0000313|Proteomes:UP000019189};
RA   Barisic I., Mitteregger D., Hirschl A.M., Noehammer C.,
RA   Wiesinger-Mayr H.;
RT   "Antibiotic resistance diversity of beta-lactamase producers in the
RT   General Hospital Vienna.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC       hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR001499}.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; prephenate
CC       biosynthesis; prephenate from chorismate: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR001499}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR001499}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CDL53724.1}.
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DR   EMBL; CBWQ010000973; CDL53724.1; -; Genomic_DNA.
DR   EnsemblBacteria; CDL53724; CDL53724; CDL53724.
DR   UniPathway; UPA00120; UER00203.
DR   UniPathway; UPA00122; UER00961.
DR   Proteomes; UP000019189; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046417; P:chorismate metabolic process; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.59.10; -; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR008244; Chor_mut/prephenate_DH_T.
DR   InterPro; IPR036263; Chorismate_II_sf.
DR   InterPro; IPR036979; CM_dom_sf.
DR   InterPro; IPR002701; CM_II_prokaryot.
DR   InterPro; IPR011277; CM_T.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003099; Prephen_DH.
DR   Pfam; PF01817; CM_2; 1.
DR   Pfam; PF02153; PDH; 1.
DR   PIRSF; PIRSF001499; Chor_mut_pdh_Tpr; 1.
DR   SMART; SM00830; CM_2; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF48600; SSF48600; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01799; CM_T; 1.
DR   PROSITE; PS51168; CHORISMATE_MUT_2; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001499};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001499};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019189};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR001499};
KW   Isomerase {ECO:0000256|PIRNR:PIRNR001499,
KW   ECO:0000313|EMBL:CDL53724.1}; NAD {ECO:0000256|PIRNR:PIRNR001499};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR001499,
KW   ECO:0000313|EMBL:CDL53724.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019189};
KW   Tyrosine biosynthesis {ECO:0000256|PIRNR:PIRNR001499}.
FT   DOMAIN        1     90       Chorismate mutase. {ECO:0000259|PROSITE:
FT                                PS51168}.
FT   DOMAIN       99    361       Prephenate/arogenate dehydrogenase.
FT                                {ECO:0000259|PROSITE:PS51176}.
SQ   SEQUENCE   373 AA;  41870 MW;  7A4F7A6B72EEE97F CRC64;
     MVAELTALRD QIDEVDKALL SLLAKRLELV AEVGEVKSQY GLPIYVPERE SAMLASRREE
     AAALGVPPDL IEDVLRRVMR ESYSSENDKG FKTLQPNLRP VVIVGGGGQM GRLFEKMLTL
     SGYQVRILEK EDWARAADIV ADAGMVIVSV PIHTTVETIA RLPPLPADCI LVDLASVKAE
     PLQAMLAAHQ GPVLGLHPMF GPDSGSLAKQ VVVYCDGRQP EAYQWFLEQI QVWGARLHRI
     SAVEHDQNMA FIQALRHFAT FAYGLHLAEE NVRLEQLLAL SSPIYRLELA MVGRLFAQDP
     QLYADIIMSS ENNLALIKRY YQRFGEAIGL LEQGDKQAFI DSFRKVEHWF GDYAQRFQSE
     SRTLLRQAND NRQ
//
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