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Database: UniProt
Entry: W1HYB3_KLEPN
LinkDB: W1HYB3_KLEPN
Original site: W1HYB3_KLEPN 
ID   W1HYB3_KLEPN            Unreviewed;       339 AA.
AC   W1HYB3;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   03-JUL-2019, entry version 23.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
OS   Klebsiella pneumoniae IS39.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=1432561 {ECO:0000313|EMBL:CDL64020.1, ECO:0000313|Proteomes:UP000019190};
RN   [1] {ECO:0000313|EMBL:CDL64020.1, ECO:0000313|Proteomes:UP000019190}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IS39 {ECO:0000313|EMBL:CDL64020.1,
RC   ECO:0000313|Proteomes:UP000019190};
RA   Barisic I., Mitteregger D., Hirschl A.M., Noehammer C.,
RA   Wiesinger-Mayr H.;
RT   "Antibiotic resistance diversity of beta-lactamase producers in the
RT   General Hospital Vienna.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CDL64020.1}.
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DR   EMBL; CBWU010000774; CDL64020.1; -; Genomic_DNA.
DR   EnsemblBacteria; CDL64020; CDL64020; CDL64020.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000019190; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019190};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019190};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156, ECO:0000313|EMBL:CDL64020.1}.
FT   DOMAIN       21    323       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   339 AA;  36858 MW;  0FF750EB3724A6BE CRC64;
     MTPEQLKAEF PLSVEQEAQI AHARQTISDI IAGRDPRLLV VCGPCSIHDP EAAIEYARRF
     KALAAEVSDS LYLVMRVYFE KPRTTVGWKG LINDPHMDGS FDVEGGLKIA RRLLVELVNM
     GLPLATEALD PNSPQYLGDL FSWSAIGART TESQTHREMA SGLSMPVGFK NGTDGSLATA
     INAMRAAAMP HRFVGINQAG QVCLLQTQGN PNGHVILRGG KAPNYGPEDV AKCEKEMAQA
     GLKPSLMVDC SHGNSNKDFR RQPAVAESVV AQIKDGNRSI IGLMIESNIH EGNQSSEQPR
     EAMKYGVSVT DACISWETTE ALLRELDKDL RGHLAARLV
//
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