ID   W1J9G4_9GAMM            Unreviewed;       863 AA.
AC   W1J9G4;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420, ECO:0000256|RuleBase:RU000604};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201, ECO:0000256|RuleBase:RU000604};
GN   Name=cya {ECO:0000313|EMBL:CDL86658.1};
GN   ORFNames=XCR1_4300007 {ECO:0000313|EMBL:CDL86658.1};
OS   Xenorhabdus cabanillasii JM26.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=1427517 {ECO:0000313|EMBL:CDL86658.1, ECO:0000313|Proteomes:UP000019197};
RN   [1] {ECO:0000313|EMBL:CDL86658.1, ECO:0000313|Proteomes:UP000019197}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JM26 {ECO:0000313|EMBL:CDL86658.1,
RC   ECO:0000313|Proteomes:UP000019197};
RA   Gualtieri M., Ogier J.C., Pages S., Givaudan A., Gaudriault S.;
RT   "Draft genome sequence and annotation of the entomopathogenic bacterium,
RT   Xenorhabdus cabanillasi strain JM26.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593,
CC         ECO:0000256|RuleBase:RU000604};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU000604}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|ARBA:ARBA00007901, ECO:0000256|RuleBase:RU004184}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDL86658.1}.
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DR   EMBL; CBXE010000369; CDL86658.1; -; Genomic_DNA.
DR   RefSeq; WP_038267184.1; NZ_NJGH01000028.1.
DR   AlphaFoldDB; W1J9G4; -.
DR   OrthoDB; 5571448at2; -.
DR   Proteomes; UP000019197; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
DR   PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998,
KW   ECO:0000256|RuleBase:RU000604}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000604};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          5..200
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   863 AA;  99254 MW;  AD43B64BBE804F70 CRC64;
     MYLYIETLKQ RLDAINQLRL ERATNSMSAA FKQVYNLIPV LLHYHHPMMP GYIKDDVPHG
     VCFFVPDETQ QFWINDLEYQ FTGVFSPSFN GELPITGIYS MGSTSSIGQS CFSDLDIWVC
     HQSWLDSGEK ALLEQKCILI EQWAASLGIE VTFFLIDENR FRHNTCGSLN GEDCGSTQHI
     LLLDEFYRTA VCMAGKRLLW AMVPVEEEGN YDEYVLSLYA QGVLTPNEWL DLGGLGELSA
     EEYFGASLWQ LYKSVDSPYK SVLKSLLLEA YSWEYPNGKL LAMEMKQHFH DGSIVSFGLD
     AYSMMLDRVT RYLTDTNDMT RLDLARRCFY LKVCEKIQEG GDDKGYSGWR QQIISQLAQE
     WGWNSDKLAM LDNRNSWKIE QVRAAHNELL DTMMQSYRNL IRFARRNNLS VSASPQDIGV
     LTRKLYAAFE ALPGKITLVN PQISLDLSEQ DLTFIYVPPG RANRSGWYLY NRAPAIESII
     GHQPLEYNRY LNKLVAWTYF NGLLAEKTRI HIHHGESQTD KKKLRNLVSD ISTHFPIRLP
     APTPKALYSP CEIRHLAIIV NLETDPTINF SDQIVHFDFR KLDVFSFGEL QQCLVDSIDL
     LYRNSWNEVR TLHFSGEQSM LEALKTILGK MHRDAAPPAS VEVFCYSEHL CGLIRTRIQQ
     LVSECIGLRL SSNRQDPNRF KALRISGQTW GLFFERLNVS VQKLENAVEF YGAISNTKLH
     GLPVKIDAKE KHLPSVIDGF ACEGIVQFFF EDIDGDQGFN IYILDESNRV EIYFHCEGSK
     EELVRDVSRF YSSSHDRFTY GSSFINFNLP QFYQIVKKGE RTHVAPFMDG KSPLDNETRS
     IIDLELDEVF RANNDPFHSL YHY
//