ID W1JA58_9GAMM Unreviewed; 164 AA.
AC W1JA58;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=HTH-type transcriptional regulator IscR {ECO:0000256|HAMAP-Rule:MF_01176};
GN Name=iscR {ECO:0000256|HAMAP-Rule:MF_01176,
GN ECO:0000313|EMBL:CDL86776.1};
GN ORFNames=XCR1_60023 {ECO:0000313|EMBL:CDL86776.1};
OS Xenorhabdus cabanillasii JM26.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=1427517 {ECO:0000313|EMBL:CDL86776.1, ECO:0000313|Proteomes:UP000019197};
RN [1] {ECO:0000313|EMBL:CDL86776.1, ECO:0000313|Proteomes:UP000019197}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JM26 {ECO:0000313|EMBL:CDL86776.1,
RC ECO:0000313|Proteomes:UP000019197};
RA Gualtieri M., Ogier J.C., Pages S., Givaudan A., Gaudriault S.;
RT "Draft genome sequence and annotation of the entomopathogenic bacterium,
RT Xenorhabdus cabanillasi strain JM26.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates the transcription of several operons and genes
CC involved in the biogenesis of Fe-S clusters and Fe-S-containing
CC proteins. {ECO:0000256|HAMAP-Rule:MF_01176}.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01176};
CC Note=Binds 1 [2Fe-2S] cluster. {ECO:0000256|HAMAP-Rule:MF_01176};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDL86776.1}.
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DR EMBL; CBXE010000453; CDL86776.1; -; Genomic_DNA.
DR RefSeq; WP_038267840.1; NZ_NJGH01000006.1.
DR AlphaFoldDB; W1JA58; -.
DR OrthoDB; 9808360at2; -.
DR Proteomes; UP000019197; Unassembled WGS sequence.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01176; HTH_type_IscR; 1.
DR InterPro; IPR010242; TF_HTH_IscR.
DR InterPro; IPR030489; TR_Rrf2-type_CS.
DR InterPro; IPR000944; Tscrpt_reg_Rrf2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR02010; IscR; 1.
DR NCBIfam; TIGR00738; rrf2_super; 1.
DR PANTHER; PTHR33221:SF5; HTH-TYPE TRANSCRIPTIONAL REGULATOR ISCR; 1.
DR PANTHER; PTHR33221; WINGED HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, RRF2 FAMILY; 1.
DR Pfam; PF02082; Rrf2; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01332; HTH_RRF2_1; 1.
DR PROSITE; PS51197; HTH_RRF2_2; 1.
PE 3: Inferred from homology;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714, ECO:0000256|HAMAP-Rule:MF_01176};
KW Activator {ECO:0000256|HAMAP-Rule:MF_01176};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01176};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|HAMAP-Rule:MF_01176};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|HAMAP-
KW Rule:MF_01176}; Metal-binding {ECO:0000256|HAMAP-Rule:MF_01176};
KW Repressor {ECO:0000256|HAMAP-Rule:MF_01176};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_01176};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_01176}.
FT BINDING 92
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01176"
FT BINDING 98
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01176"
FT BINDING 104
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01176"
SQ SEQUENCE 164 AA; 18034 MW; F85E665DB5A66331 CRC64;
MRLTSKGRYA VTAMLDVALH SQEGPVPLAD ISERQGISLS YLEQLFSRLR KNGLVSSVRG
PGGGYLLGRD AGEIFVAEVI SAVDESVDAT RCQGREGCQG GDRCLTHALW RDLSDRITSF
LNSISLEELV NNQEVLDVAD RQDSDKRRTA NGRVQEMINI NLRA
//
