ID W1NL63_AMBTC Unreviewed; 819 AA.
AC W1NL63;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=AMTR_s00001p00110790 {ECO:0000313|EMBL:ERM96201.1};
OS Amborella trichopoda.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Amborellales; Amborellaceae; Amborella.
OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERM96201.1, ECO:0000313|Proteomes:UP000017836};
RN [1] {ECO:0000313|Proteomes:UP000017836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24357323;
RG Amborella Genome Project;
RT "The Amborella genome and the evolution of flowering plants.";
RL Science 342:1241089-1241089(2013).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; KI397142; ERM96201.1; -; Genomic_DNA.
DR RefSeq; XP_006828785.1; XM_006828722.2.
DR AlphaFoldDB; W1NL63; -.
DR STRING; 13333.W1NL63; -.
DR EnsemblPlants; ERM96201; ERM96201; AMTR_s00001p00110790.
DR GeneID; 18424128; -.
DR Gramene; ERM96201; ERM96201; AMTR_s00001p00110790.
DR KEGG; atr:18424128; -.
DR eggNOG; KOG2189; Eukaryota.
DR HOGENOM; CLU_005230_0_0_1; -.
DR OMA; SKIVKIC; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000017836; Unassembled WGS sequence.
DR GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000017836};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 422..446
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 467..484
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 547..565
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 577..600
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 636..654
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 756..777
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 99..133
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 819 AA; 93246 MW; C21021092180791E CRC64;
MATNGCCPPM DLFRSEPMQL VQLIIPMESA HQTVSYLGET GLFQFKDLNA EKSPFQRTYA
NQIKRCGEMA RKLRFFKEQM SKAGISPSTR SASSPDIDLD DLEIKLGELE AELIEVNSNN
EKLQRTYNEL MEYKLVLEKA GEFFYSARRD ATAQQREIEE SLQVGEGSID SPLLLEQEML
TDPSKQVKLG FVSGLVPKAK SMAFERILFR ATRGNMYLKQ SVVEGPVTDP VSGEKVEKNV
FVVFYSGERA KMKILKICEA FGANRYPFPE DFGKQRQMIG EVSGKTMDLK TTIDIGLRHR
NNVLEIISYQ FEQWNILVRK EKAVFHTLNM LSMDVTKKCL VAEGWSPVFA KSQIQGTLQR
ATRDSNSQVG AIFQVLRTKE SPPTYFRANK FTSAFQEIVD AYGVARYQEA NPGVYTIVTF
PFLFAVMFGD WGHGICLLLA ALILVFKEKK LSSQKLGDIL EMTFGGRYVI LMMSLFSIYT
GLIYNEFFSV PFSLFGRSAY ECREPSCSDA YTGGLIKVRD AYPFGVDPTW HGSRTELPFL
NSLKMKMSIL LGVAQMNLGI VLSYFNARFF GNYVNVWYQF VPQMIFLNSL FGYLSVLVIV
KWCTGSTADL YHIMIYMFLS PTDDLGENQL FFGQKTLQLV LLLLALVSVP WMLFPKPFIL
KKQYDDRHRG HSYDVIPTTD PDSFEMEAGH DSHGHEEFEF SEVFVHQLIH TIEFVLGAVS
NTASYLRLWA LSLAHSELSS VFYEKVLILA WGYNNIFILI IGFIVFAFAT IGVLLIMETL
SAFLHALRLH WVEFQNKFYE GDGYKFLPFA FSLLGEEDD
//
