ID W1NT45_AMBTC Unreviewed; 283 AA.
AC W1NT45;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=glycine hydroxymethyltransferase {ECO:0000256|ARBA:ARBA00012256};
DE EC=2.1.2.1 {ECO:0000256|ARBA:ARBA00012256};
GN ORFNames=AMTR_s00095p00053900 {ECO:0000313|EMBL:ERM98130.1};
OS Amborella trichopoda.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Amborellales; Amborellaceae; Amborella.
OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERM98130.1, ECO:0000313|Proteomes:UP000017836};
RN [1] {ECO:0000313|Proteomes:UP000017836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24357323;
RG Amborella Genome Project;
RT "The Amborella genome and the evolution of flowering plants.";
RL Science 342:1241089-1241089(2013).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777}.
CC -!- SIMILARITY: Belongs to the SHMT family.
CC {ECO:0000256|ARBA:ARBA00006376}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI395483; ERM98130.1; -; Genomic_DNA.
DR AlphaFoldDB; W1NT45; -.
DR STRING; 13333.W1NT45; -.
DR EnsemblPlants; ERM98130; ERM98130; AMTR_s00095p00053900.
DR Gramene; ERM98130; ERM98130; AMTR_s00095p00053900.
DR eggNOG; KOG2467; Eukaryota.
DR HOGENOM; CLU_085859_0_0_1; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000017836; Unassembled WGS sequence.
DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR001085; Ser_HO-MeTrfase.
DR InterPro; IPR039429; SHMT-like_dom.
DR PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR11680:SF7; SERINE HYDROXYMETHYLTRANSFERASE 7; 1.
DR Pfam; PF00464; SHMT; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000017836};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 139..268
FT /note="Serine hydroxymethyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF00464"
SQ SEQUENCE 283 AA; 31879 MW; 29C53DB191509A84 CRC64;
MDISDTRSNL SLRFNVHSIS DKHEAYGPVR TPIADDSIYF QLDSSFSNDQ SSNSASSIPL
QLLEQSDYGN CVEDTEVEEQ TEEEFSILGY PMCLKRRRER EGSVVSAQKR QQHESCSPSP
MDLEARRMAI RAWGKQPLAT IDPDLWALME KEKQRQWKGI QRVSENFVCQ AVLEALGSHL
TNKYSEGLPG SRYYGGNQFI DQIELLCCER ALAAFYLDSE KWGVNVQAYL CTSANFAVYT
GLIFPKDRIM GLDSPSGGHS SNGYYTPGGK SVFGAWIFFK KTK
//
