ID W1NWS6_AMBTC Unreviewed; 411 AA.
AC W1NWS6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=AMTR_s00101p00160970 {ECO:0000313|EMBL:ERM99134.1};
OS Amborella trichopoda.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Amborellales; Amborellaceae; Amborella.
OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERM99134.1, ECO:0000313|Proteomes:UP000017836};
RN [1] {ECO:0000313|Proteomes:UP000017836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24357323;
RG Amborella Genome Project;
RT "The Amborella genome and the evolution of flowering plants.";
RL Science 342:1241089-1241089(2013).
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class dual specificity subfamily.
CC {ECO:0000256|ARBA:ARBA00008601}.
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DR EMBL; KI395058; ERM99134.1; -; Genomic_DNA.
DR RefSeq; XP_006836281.1; XM_006836218.2.
DR RefSeq; XP_011620738.1; XM_011622436.1.
DR AlphaFoldDB; W1NWS6; -.
DR STRING; 13333.W1NWS6; -.
DR EnsemblPlants; ERM99134; ERM99134; AMTR_s00101p00160970.
DR GeneID; 18427164; -.
DR Gramene; ERM99134; ERM99134; AMTR_s00101p00160970.
DR KEGG; atr:18427164; -.
DR eggNOG; KOG1716; Eukaryota.
DR HOGENOM; CLU_023312_1_2_1; -.
DR OMA; FAWQGMQ; -.
DR OrthoDB; 5472710at2759; -.
DR Proteomes; UP000017836; Unassembled WGS sequence.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR016278; DUSP12.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR45848:SF4; DUAL SPECIFICITY PROTEIN PHOSPHATASE 12; 1.
DR PANTHER; PTHR45848; DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER; 1.
DR Pfam; PF00782; DSPc; 1.
DR PIRSF; PIRSF000941; DUSP12; 2.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000017836}.
FT DOMAIN 92..241
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 161..217
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 62..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 185
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000941-50"
SQ SEQUENCE 411 AA; 45537 MW; C7C28D017785B886 CRC64;
MPTLVRNGLF IGDINDAAEV LCHGSSGITH VLSLLSSASI SFFSDWQSSI VIPTKEIRRV
FANPNPNSKD RSVSQNPSFS LHDQVPSSQF PKPTPEHTQS LASGSQTRTP CSVDKAMDKL
SLKPDSSSGE KLLFVLEMAG QDLKLARMAV PLRDMESENL LDYLEVCLDF INKSRADGGT
VLVHCFAGVS RSAAVITAYL MRTEQLSQED ALESLRQCCE SVCPNDGFLD QLKMFEEMGF
KVDPASSIYK HFHLKRLGDA YIKGEKIDSI KFGADPGALV LQDKTSSQEQ ETTQDKPKLS
YRCKKCRRVV ALEDNVLAHM PGEGETCFGW QKRKSGNPFG RHDEHECSSI FVEPLKWMTI
VEEGAIEGKL LCVHCEARLG YFNWSGIQCS CGSWVTPAFQ LHKSRIDIST A
//
