ID W1P3C7_AMBTC Unreviewed; 570 AA.
AC W1P3C7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Histone acetyltransferase GCN5 {ECO:0000256|ARBA:ARBA00019713};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN ORFNames=AMTR_s00002p00268390 {ECO:0000313|EMBL:ERN01460.1};
OS Amborella trichopoda.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Amborellales; Amborellaceae; Amborella.
OX NCBI_TaxID=13333 {ECO:0000313|EMBL:ERN01460.1, ECO:0000313|Proteomes:UP000017836};
RN [1] {ECO:0000313|Proteomes:UP000017836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24357323;
RG Amborella Genome Project;
RT "The Amborella genome and the evolution of flowering plants.";
RL Science 342:1241089-1241089(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the acetyltransferase family. GCN5 subfamily.
CC {ECO:0000256|ARBA:ARBA00008607}.
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DR EMBL; KI394767; ERN01460.1; -; Genomic_DNA.
DR AlphaFoldDB; W1P3C7; -.
DR STRING; 13333.W1P3C7; -.
DR EnsemblPlants; ERN01460; ERN01460; AMTR_s00002p00268390.
DR Gramene; ERN01460; ERN01460; AMTR_s00002p00268390.
DR eggNOG; KOG1472; Eukaryota.
DR HOGENOM; CLU_015741_5_0_1; -.
DR OMA; FAQPVNR; -.
DR OrthoDB; 1760108at2759; -.
DR Proteomes; UP000017836; Unassembled WGS sequence.
DR GO; GO:0000123; C:histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0010484; F:histone H3 acetyltransferase activity; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd05509; Bromo_gcn5_like; 1.
DR CDD; cd04301; NAT_SF; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR037800; GCN5.
DR InterPro; IPR000182; GNAT_dom.
DR PANTHER; PTHR45750; GH11602P; 1.
DR PANTHER; PTHR45750:SF3; HISTONE ACETYLTRANSFERASE; 1.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51186; GNAT; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000017836};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 228..375
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
FT DOMAIN 473..544
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..75
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..136
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 570 AA; 64334 MW; EB04F39B91E65EC4 CRC64;
MDVHSGQSGG GGGVLSRSRA TSQSPSPSHS ASASVSATSA HPLTTSTTTH PNPNKRKLPS
SPHHLPPPHP HPPSHPLSLS NDDLDSLSAR ADSDPVSLSN SEDRSEEEEE NSEEEEEENS
EEEEEEMEDD EEDDDSMRTF TNARLSSKPK GEVGSSGIEK VSELGVKEER EKDRGSNQVA
GSGLAVKDDS VKSVFTDNIQ TSGAYCARED SLKKEEDAGR LKFVCFANDG VDEHMIWLIG
LKNIFARQLP NMPKEYIVRL VMDRSHKSVM IIKNNQVVGG ITYRPYVGQK FGEIAFCAIA
TDEQVKGYGT RLMNHLKQHA RDVDGLTHFL TYADNNAVGY FIKQGFSKEI ELERERWQGY
IKDYDGGILM ECKIDPKLPY TDLSAMIRQQ RQAIDEKIRE LSNCHIIYPG IDFQKKEAGI
SRKKVEDIPG LREAGWTPDQ WGHTRFRAFS PAEIPNHRQQ LNSFMRSLHK VLSEHADAWP
FKEPVDARDV PDYYDVIKDP MDLRTMSKRL ESEQYYVTFE MFVADVKRMF ANARTYNSPD
TIYYKLANRL ESFFSNKVQA WLQASTKGQQ
//
