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Database: UniProt
Entry: W1Q526_ABIDE
LinkDB: W1Q526_ABIDE
Original site: W1Q526_ABIDE 
ID   W1Q526_ABIDE            Unreviewed;       433 AA.
AC   W1Q526;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   05-JUN-2019, entry version 30.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   ORFNames=GCWU000182_000042 {ECO:0000313|EMBL:ESK66355.1};
OS   Abiotrophia defectiva ATCC 49176.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Aerococcaceae;
OC   Abiotrophia.
OX   NCBI_TaxID=592010 {ECO:0000313|EMBL:ESK66355.1, ECO:0000313|Proteomes:UP000019050};
RN   [1] {ECO:0000313|EMBL:ESK66355.1, ECO:0000313|Proteomes:UP000019050}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49176 {ECO:0000313|EMBL:ESK66355.1,
RC   ECO:0000313|Proteomes:UP000019050};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B.,
RA   Courtney L., Fronick C., Harrison M., Strong C., Farmer C.,
RA   Delahaunty K., Markovic C., Hall O., Minx P., Tomlinson C.,
RA   Mitreva M., Nelson J., Hou S., Wollam A., Pepin K.H., Johnson M.,
RA   Bhonagiri V., Nash W.E., Warren W., Chinwalla A., Mardis E.R.,
RA   Wilson R.K.;
RL   Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ESK66355.1}.
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DR   EMBL; ACIN03000001; ESK66355.1; -; Genomic_DNA.
DR   RefSeq; WP_023390703.1; NZ_KI535340.1.
DR   STRING; 592010.GCWU000182_000042; -.
DR   EnsemblBacteria; ESK66355; ESK66355; GCWU000182_000042.
DR   OrthoDB; 1626282at2; -.
DR   BioCyc; GCF_000160075-HMP:GCWU000182_RS00205-MONOMER; -.
DR   Proteomes; UP000019050; Unassembled WGS sequence.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; -; 1.
DR   Gene3D; 4.10.320.10; -; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF47005; SSF47005; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019050};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423, ECO:0000256|SAAS:SAAS00065550};
KW   Pyruvate {ECO:0000313|EMBL:ESK66355.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019050};
KW   Transferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:ESK66355.1}.
FT   DOMAIN        2     77       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN      126    163       Peripheral subunit-binding (PSBD).
FT                                {ECO:0000259|PROSITE:PS51826}.
FT   REGION       78    123       Disordered. {ECO:0000256|MobiDB-lite:
FT                                W1Q526}.
SQ   SEQUENCE   433 AA;  45451 MW;  7E030DE7EB84C6FD CRC64;
     MAFKFRLPDI GEGIAEGEIV KWDVKEGDTI QEDDTLVEIQ NDKSVEEIPS PVTGKILKIL
     VQEGTVARVG DVLVEIDAPG HEDDGDAAPA AEAAPEAAPA AEAAPAAPAG PGAPTGAPAG
     EGKRVLAMPS VRKLARDKGV DIRLVTPSGK GGRVVAADVL AFNGEAAPVA AAEVAAPAQA
     ASVAAAPAAP AQPYVSGKGE AETREPLSPM RKAISKAMVN SKHTAPHVTL FDEVEVSALW
     DHRKKFKDIA ANRGTKLTFL PYVVKALVAT VKKFPVLNAS IDDASQEIVY KNYYNIGIAT
     DTERGLFVPN VKDANTKSVF DIADEINGKA ALAHEGKLTA QDMSQGTITI SNIGSARGQW
     FTPIINYPEV AILGMGTINV QPVVNAEGEI AVGRMLKLSL SFDHRIVDGA TAQNAMNELK
     RLLADPELLL MEG
//
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