ID W1Q6Z0_OGAPD Unreviewed; 893 AA.
AC W1Q6Z0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Putative membrane protein {ECO:0000313|EMBL:ESW95979.1};
GN ORFNames=HPODL_02622 {ECO:0000313|EMBL:ESW95979.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ESW95979.1, ECO:0000313|Proteomes:UP000008673};
RN [1] {ECO:0000313|EMBL:ESW95979.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
RN [2] {ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RA Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT "Genome sequence of the methylotrophic yeast Hansenula polymorpha DL1.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESW95979.1}.
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DR EMBL; AEOI02000010; ESW95979.1; -; Genomic_DNA.
DR RefSeq; XP_013932409.1; XM_014076934.1.
DR AlphaFoldDB; W1Q6Z0; -.
DR STRING; 871575.W1Q6Z0; -.
DR GeneID; 25772074; -.
DR KEGG; opa:HPODL_02622; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_2_1_1; -.
DR OMA; NWACVAL; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000008673; Chromosome VII.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF143; PHOSPHATE METABOLISM PROTEIN 7; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..162
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 185..367
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 379..651
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 799..886
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 874..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 100027 MW; 3EFD5D1CB210BDD8 CRC64;
MASQTQSSSS VSAFVSALIL NLIIFAVFLT VFVVCKDKFK RVYQPRSTVD TVPSRLKADP
QPRGAFAWIS FILSKPESYI IEKAGVDGYF FLRYILTFAS LGIVGGLFIW PVLFSVNATG
GAHQKGFDII SYSNNAGRWR SFAHVFCSWL FFGLVIYTIY KELIYYTSFR HALQTTPLYS
SLISSKTLFI DNVPDSMLDE DTLHRLFPAA VNVWYTRDTK ELQDLIKKRT KLSGKLENSI
VKVVGKAIKL RTKAAKKNKP VPEPANEITS YIPEKKLPTY KDSWIPFFGK KKSLFTTGID
ELGEYNKKIN DEQLKYPDGF EKTGSVFIEF ANHLELQRAY QGVPYSKELK YSRRFTSIAP
DDVVWENSGL TAKVRAGKRS IAITILTLLI IFWAIPVAVV GAISNINYLT EKVHFLRFIN
NMPSVLMGII TALLPTIALA VLMMLLPPFI RKMGKLSGCM TAQSVDFWTQ QWYYGFQVVQ
VFLVATCTSA AASSVSDVIE NPSSAMPLLG QKLPAAANFY ISYMLLQGLS ISSGALAQIV
GLILSFFLGR ILDGTPRKKW NRYNTLGTPS WGTTYAAFGL FTVIMLVYSI ISPIIIAFTT
IAYFLIYVAY LYNLNYVLDR NVDNRGRNYP LALFEVFVGL YLAELCLIAL FVMPKNWACV
VLEAVMLAAT VAAHLYCRWK FEPLLDTVPV GAMKEANGGI VGAYPMSDQG LRQIREEGQT
YFVADGSDSS KFSEYGGGAK QHSLASDSHT AATDLEKIGT LDNEERPFNQ ANVTEEQVNK
FDARRYASAS FVKGYVNRYF KPRTYLSFNY VRSILPVSWQ DPVPDQGLTF KDPAASVDEP
YLWIARDSQG LSRSFVERCQ GKLLISDENA VVEDNGKNRY TGPPPDYTDI QKA
//
