ID W1QBF4_OGAPD Unreviewed; 589 AA.
AC W1QBF4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=mRNA export factor MEX67 {ECO:0000313|EMBL:ESW98376.1};
GN ORFNames=HPODL_04004 {ECO:0000313|EMBL:ESW98376.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ESW98376.1, ECO:0000313|Proteomes:UP000008673};
RN [1] {ECO:0000313|EMBL:ESW98376.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
RN [2] {ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RA Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT "Genome sequence of the methylotrophic yeast Hansenula polymorpha DL1.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NXF family. {ECO:0000256|ARBA:ARBA00009285}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESW98376.1}.
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DR EMBL; AEOI02000008; ESW98376.1; -; Genomic_DNA.
DR RefSeq; XP_013934259.1; XM_014078784.1.
DR AlphaFoldDB; W1QBF4; -.
DR STRING; 871575.W1QBF4; -.
DR GeneID; 25773435; -.
DR KEGG; opa:HPODL_04004; -.
DR eggNOG; KOG3763; Eukaryota.
DR HOGENOM; CLU_024991_1_1_1; -.
DR OMA; YGGHEAW; -.
DR OrthoDB; 10284at2759; -.
DR Proteomes; UP000008673; Chromosome V.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0051641; P:cellular localization; IEA:UniProt.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR CDD; cd14342; UBA_TAP-C; 1.
DR Gene3D; 3.10.450.50; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR040736; Mex67_RRM.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR InterPro; IPR030217; NXF_fam.
DR InterPro; IPR005637; TAP_C_dom.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR10662; NUCLEAR RNA EXPORT FACTOR; 1.
DR PANTHER; PTHR10662:SF22; NUCLEAR RNA EXPORT FACTOR 1; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF18444; RRM_9; 1.
DR Pfam; PF03943; TAP_C; 1.
DR SMART; SM00804; TAP_C; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50177; NTF2_DOMAIN; 1.
DR PROSITE; PS51281; TAP_C; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 295..488
FT /note="NTF2"
FT /evidence="ECO:0000259|PROSITE:PS50177"
FT DOMAIN 537..589
FT /note="TAP-C"
FT /evidence="ECO:0000259|PROSITE:PS51281"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 589 AA; 64837 MW; 70FF5D1579EE3BF6 CRC64;
MFQNTFGLNA SNTGNQHSSS NMSPSGSDWT QNNGILVEIT GWTNADEKDL SSFIHRKTKI
NIRIIQADRK TGILKASVKT DGDANTLSKC NGIRFAGNIL RVKVLSSPGT TLAAGGNSTV
ALIKSALSSR YDSTSRLLNL DGIRNDVNPE LRGVLSNSQT ASKFFLAMLK IALQEQYKID
SLNLSNNNLG NNSRDLIEMA ASLPDLQNLA LSNNNITKLD ALEKLKNKLP RLRELWITGN
PVDNPTSTGE IIKFFPRLTI LNGLPVRDES KLTKLLSFPI PNQSSFFESS DLQRVSIEFT
TTYLRLWDHD RTSLISLFSP ESQFSYHFDT THIVDAPIAS IDSKVPRMPH SVASSWGSYI
SNSRNLMRVS GLRPRMSKVF KGGEQIIQAF RSLPGTKHEL EENPQNYSIE VVSVPTLNAM
QILIHGGFKE VSPPVATGKD SNSRQGNRFG APSASSRTSL ETRSFDRSLM VIAGPNGSYI
VASDMLLLKP FSGLGAWCPK FSLDPIPSFS SPSNEQVATN AVDPISIPSD IAANLNITQQ
QLLCKIMTET NLVLQYSLLL CEQSNWDYGT ALMNFQNSRS QIPREAFHS
//
