ID W1QCH2_OGAPD Unreviewed; 168 AA.
AC W1QCH2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 9 {ECO:0000256|ARBA:ARBA00020636, ECO:0000256|RuleBase:RU364145};
DE AltName: Full=Mediator complex subunit 9 {ECO:0000256|ARBA:ARBA00031260, ECO:0000256|RuleBase:RU364145};
GN Name=MED9 {ECO:0000256|RuleBase:RU364145};
GN ORFNames=HPODL_01511 {ECO:0000313|EMBL:ESW97412.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ESW97412.1, ECO:0000313|Proteomes:UP000008673};
RN [1] {ECO:0000313|EMBL:ESW97412.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
RN [2] {ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RA Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT "Genome sequence of the methylotrophic yeast Hansenula polymorpha DL1.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364145}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364145}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364145}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 9 family.
CC {ECO:0000256|ARBA:ARBA00008089, ECO:0000256|RuleBase:RU364145}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESW97412.1}.
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DR EMBL; AEOI02000009; ESW97412.1; -; Genomic_DNA.
DR RefSeq; XP_013933497.1; XM_014078022.1.
DR AlphaFoldDB; W1QCH2; -.
DR GeneID; 25770972; -.
DR KEGG; opa:HPODL_01511; -.
DR eggNOG; ENOG502SFWY; Eukaryota.
DR HOGENOM; CLU_1586975_0_0_1; -.
DR OrthoDB; 1976671at2759; -.
DR Proteomes; UP000008673; Chromosome VI.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR011425; Med9.
DR Pfam; PF07544; Med9; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364145};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364145};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364145};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364145}.
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 40..67
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 168 AA; 18760 MW; 994FA121DF307383 CRC64;
MSTGLSGLSR ASGSPENLST PGFKAALKTE SDTNTPVFAA MDHSSSLKKE IDEYEQLNNE
ARALEELRNM DLLPLLLDLI ENLKAGKISP KDFDNATGRI KTRLNKFRSL LNQIEGLDES
TESRIQKMEE MKKRIGAKQE LLKRFSEEIE AKFGTGRPIA GDKMEIDE
//
