ID W1QE88_OGAPD Unreviewed; 830 AA.
AC W1QE88;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=DNA mismatch repair protein PMS1 {ECO:0000313|EMBL:ESW99759.1};
GN ORFNames=HPODL_03630 {ECO:0000313|EMBL:ESW99759.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ESW99759.1, ECO:0000313|Proteomes:UP000008673};
RN [1] {ECO:0000313|EMBL:ESW99759.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
RN [2] {ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RA Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT "Genome sequence of the methylotrophic yeast Hansenula polymorpha DL1.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESW99759.1}.
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DR EMBL; AEOI02000007; ESW99759.1; -; Genomic_DNA.
DR RefSeq; XP_013935431.1; XM_014079956.1.
DR AlphaFoldDB; W1QE88; -.
DR STRING; 871575.W1QE88; -.
DR GeneID; 25773066; -.
DR KEGG; opa:HPODL_03630; -.
DR eggNOG; KOG1978; Eukaryota.
DR HOGENOM; CLU_004131_0_2_1; -.
DR OMA; RCSKIRS; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000008673; Chromosome IV.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 2.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673}.
FT DOMAIN 216..347
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 635..784
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 362..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 92393 MW; 7F15CEBCDF35DED5 CRC64;
MTLTRIGTAD VHNITSGQVI IDLSTASKEL LENSLDAGAT QVTITFKNHG IDSIEVSDNG
TGIDEEDFDG ICMKHYTSKL RTFEDVANVR TLGFRGEALS SLCAVARVDI TTSTKSIQPR
AYKLEYDHHG RLKSKQTASR NCGTTVLISD IFRNLPVRKT DLVKNGRREF QKAVTLLQSY
ALIKVGLRLV VQHVDSRGRK GIMLATSGSK QLRSNVLSVF GANGMAGLEP IDFRLNISAR
FKLKACDMLL SVHGYLSNCS FGKGRSATDR QFWFVNGRPV KLQQFSKAIT DVYKTFNHLQ
CPVILLDLEL DPQFIDVNVT PDKRTIFLHN EAAIIEALKE RVTEIFSSQD ISIPKSQLTM
ERSRDNRLVK DGAAEVNQRE TGCDLDPEEE DGEKEEHEGY EEERSKDESD EGRADVSDID
ESGAQKLAEA QSTDTVTPIS PGTIHASESE GEAGPADIDD TLESISKSPV SMQVQSTLKT
QFDKNAEVNT STPDSEPGTA EFSKVDDQIL SSDTNESNEV SFDRRLGIGR ETSSPLRMTV
RDKYIETHPT GQRKLSFEPK SEKRTASATL TRTQSSLHDT ELPIKASPGS FKMQKPKLEK
SAGTRAAVDD ITDESDAERK LTLSVSKKDF LEMQVIGQFN LGFILVTKQD KSGTHLFIID
QHASDEKYNF ERYQTETVFN NQPLVIPQQL HLNIIDELAI MNNLEVFGKN GFGLRVDEDA
QPGERLSLTS LPYSKDTTFG LSDLDELVHL VKEHHGRGVL RPSKVRAMLA MRACRTSIMI
GKPLSHKTMT SVVRNLAALD KPWNCPHGRP TMRHLIELKN WATFSKDYET
//
