ID W1QIX0_OGAPD Unreviewed; 626 AA.
AC W1QIX0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
GN ORFNames=HPODL_04561 {ECO:0000313|EMBL:ESX01787.1};
OS Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=871575 {ECO:0000313|EMBL:ESX01787.1, ECO:0000313|Proteomes:UP000008673};
RN [1] {ECO:0000313|EMBL:ESX01787.1, ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RX PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA Skryabin K.G.;
RT "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT DL1.";
RL BMC Genomics 14:837-837(2013).
RN [2] {ECO:0000313|Proteomes:UP000008673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1
RC {ECO:0000313|Proteomes:UP000008673};
RA Ravin N.V., Mardanov A.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V.,
RA Zvereva M.I., Smekalova E.M., Dontsova O.A., Skryabin K.G.;
RT "Genome sequence of the methylotrophic yeast Hansenula polymorpha DL1.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Adaptins are components of the adaptor complexes which link
CC clathrin to receptors in coated vesicles. Clathrin-associated protein
CC complexes are believed to interact with the cytoplasmic tails of
CC membrane proteins, leading to their selection and concentration.
CC {ECO:0000256|PIRNR:PIRNR002291}.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR002291}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESX01787.1}.
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DR EMBL; AEOI02000004; ESX01787.1; -; Genomic_DNA.
DR RefSeq; XP_013936373.1; XM_014080898.1.
DR AlphaFoldDB; W1QIX0; -.
DR STRING; 871575.W1QIX0; -.
DR GeneID; 25773989; -.
DR KEGG; opa:HPODL_04561; -.
DR eggNOG; KOG1061; Eukaryota.
DR HOGENOM; CLU_006320_4_4_1; -.
DR OMA; RIFARYK; -.
DR OrthoDB; 648032at2759; -.
DR Proteomes; UP000008673; Chromosome II.
DR GO; GO:0030117; C:membrane coat; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR026739; AP_beta.
DR InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR PANTHER; PTHR11134; ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER; 1.
DR PANTHER; PTHR11134:SF13; AP-2 COMPLEX SUBUNIT BETA; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR PIRSF; PIRSF002291; AP_complex_beta; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|PIRNR:PIRNR002291};
KW Protein transport {ECO:0000256|PIRNR:PIRNR002291};
KW Reference proteome {ECO:0000313|Proteomes:UP000008673};
KW Transport {ECO:0000256|PIRNR:PIRNR002291}.
FT DOMAIN 24..537
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
FT REGION 596..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 626 AA; 70368 MW; F64A910E8612889C CRC64;
MASSNLYTRV RAAEIVNELR ANEKKSRSAV FRKTALKKIV ANMTLGNNEM VGLSNEVLAI
TLDLANDTEA KRLGYLFFST YYPQRPHDCV NLLPLLEKDF QSESAVLRSL SIRTLATIQI
PEFLAKASVL VCEAMDDKDP HVRKTGVYAV SRIYGRAPEE VRQQFLKGLN RLLHDPTVFV
VAAAVDCLRD LVENHDGLQF SIDRNNCFRI VELLAGCDEW SQVSLLNSVM AFVPQTEADA
ISLAEKCIPL LQHGNSSVVL NALKVIVYLS NYVRNFVDVL PAITKRVSGC ISNLMSKPAE
IQFLTMRNVI LLLLDKAELL ELQVSMFFCQ FDDPVYIKDT KLELIFLLAN ESNISLVLRE
LEEYALEIDD QMVRKSIRAI GNLAIKIPSV ADRSIEVLSG LLASSLPHIV QEVAIILKDI
LRKYPGKYLY LIDLLVQNVD LLTDSDSRGS FIWILGEYCN SIPGSADILQ KLYANFDNEP
TQVQLTTLTA LVKTYLCLPS KQTETLVLDV LRKTTEEANE PDLRERAFFY WRLLSSHKDI
KDIVKPVLPI IEVSSDKLPP EILEELELNI GSLASIYLRP VQQVFRLSKP RRLPVSPALT
RTESRDSSVP FSSPVSRNTS ATSVYK
//
