ID W1TKI3_9ACTO Unreviewed; 1233 AA.
AC W1TKI3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=nitrate reductase (quinone) {ECO:0000256|ARBA:ARBA00012500};
DE EC=1.7.5.1 {ECO:0000256|ARBA:ARBA00012500};
GN ORFNames=Q618_VCMC00003G0283 {ECO:0000313|EMBL:ETI81981.1};
OS Varibaculum cambriense DORA_20.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Varibaculum.
OX NCBI_TaxID=1403948 {ECO:0000313|EMBL:ETI81981.1, ECO:0000313|Proteomes:UP000018843};
RN [1] {ECO:0000313|EMBL:ETI81981.1, ECO:0000313|Proteomes:UP000018843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DORA_20 {ECO:0000313|Proteomes:UP000018843};
RA Brown C.T., Sharon I., Thomas B.C., Castelle C.J., Morowitz M.J.,
RA Banfield J.F.;
RT "A Varibaculum cambriense genome reconstructed from a premature infant gut
RT community with otherwise low bacterial novelty that shifts toward anaerobic
RT metabolism during the third week of life.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinol + nitrate = a quinone + H2O + nitrite;
CC Xref=Rhea:RHEA:56144, ChEBI:CHEBI:15377, ChEBI:CHEBI:16301,
CC ChEBI:CHEBI:17632, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.7.5.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001854};
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. {ECO:0000256|ARBA:ARBA00010312}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETI81981.1}.
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DR EMBL; AZMI01000003; ETI81981.1; -; Genomic_DNA.
DR AlphaFoldDB; W1TKI3; -.
DR STRING; 184870.HMPREF1862_01924; -.
DR PATRIC; fig|1403948.3.peg.1782; -.
DR eggNOG; COG5013; Bacteria.
DR Proteomes; UP000018843; Unassembled WGS sequence.
DR GO; GO:0009325; C:nitrate reductase complex; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0008940; F:nitrate reductase activity; IEA:InterPro.
DR GO; GO:0042126; P:nitrate metabolic process; IEA:InterPro.
DR CDD; cd02776; MopB_CT_Nitrate-R-NarG-like; 1.
DR Gene3D; 3.40.50.12440; -; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR037943; MopB_CT_Nitrate-R-NarG-like.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR006655; Mopterin_OxRdtase_prok_CS.
DR InterPro; IPR027467; MopterinOxRdtase_cofactor_BS.
DR InterPro; IPR006468; NarG.
DR NCBIfam; TIGR01580; narG; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR PANTHER; PTHR43105:SF2; RESPIRATORY NITRATE REDUCTASE 2 ALPHA CHAIN; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1.
DR PROSITE; PS00490; MOLYBDOPTERIN_PROK_2; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018843}.
FT DOMAIN 44..108
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 1233 AA; 136802 MW; 1222ED649A2E12E0 CRC64;
MAGSSLLKLG AKLRRGQVSQ DARQMFLVGG READAFYRQR FSHDKVVRST HGVNCTGSCS
WRVFVKDGLI TWEAQAVDYP STGPDMPDYE PRGCPRGAAF SWYEYSPTRI RHPYVRSVLL
DAYRKAKQTH PDPVDAFRAV ASDPVASAAY KSARGKGGMV RTSWEEALEI VAAANVSTIK
DYGPDRIAGF SVLPAMSMVS FGAGARYLQL IGGVNLSFYD WYADLPVASP QVFGDQTDVP
EAGDWFNSSY LLVWGSNLPL TRTPDAHFMT EARYHGQKMV SINPDYSDNT KFADEWLRVN
PGTDGALATA MGHVILNEFH VGKQSQYFLD YMRSYTDSPF LVKLEETPEG LVPGKFLSAT
DVSSLPAETK EKPKPEFRFL VMDADGNVKD PGGTLADRFT PEGKGHWNLK MKGVNAQLSL
YQEGGESAEI TLPRFDLVAG ENKGGSVGAG TIKRGVPIRK VDGHLVTTVY DILLAQYGVK
RTGLPGAWGK DYQDPATPGT PAWAEEITGV PANATIRIAR EFAQNALDSK GRSQIVLGAG
TNHYFHSDQI YRTILALTSM CGTQGVNGGG WAHYVGQEKV HPITGWTQYS FALDWQRPAR
QMISTGFWYL TTDQWRYDSL TTDRLTSPAS AAKVPTQNIA DSLLEATERG WMPAYPQFNR
SSLELGRQAQ ESGQKPADYV AAQLAAGKLE FAAKDPDNPV NYPRVLINWR TNLLGSSAKG
TEFFLRHMIG ADNDVQAEEV SEDQRPRNVR WREQAAKGKL DLVVTADFRN TSTTLHSDVV
LPAATWYEKH DLSSTDMHPY VHTFNAAILP PWQARTDFQL FQDLAQLVSK MAGNHLGTQL
DLLAAPLNHD SPDELANPAG IVIPREECGW VPGVNMPKII PIERDYTKIG EKFNSLGPVI
EKMGMGTKGV PFTPDKELRE MREQFGEIET AIGPRPRLDT DQIAAEFILK FSGTTNGRLA
TQGFETLTEK VGAAGDMTEM SRGHADYQIT LTDVQQAPKT VVTSPEWSGS EHGGRRYTAF
SQNVEYLKPW HTLTGRMHYY LDHDWMCAYG ESLPTYRPPL DLHHLFGEPA PGMVRGDGTP
SAEVAVRYLT PHNKWAIHSQ YFDNLYMLTL GRGGQTVWMS PQDAAKIGVR DNEWIEAHNR
NGVVSARAIV SHRIPEGTVF MHHAQERITH TPLNQSTGKR GGTHNSLTRI FIKPTHLLGG
YGQFSYAFNY TGPTGNQRDE VTYIRRRSQE VEF
//