ID   W1TMH8_9ACTO            Unreviewed;       439 AA.
AC   W1TMH8;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETI82812.1};
GN   ORFNames=Q618_VCMC00001G0393 {ECO:0000313|EMBL:ETI82812.1};
OS   Varibaculum cambriense DORA_20.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Varibaculum.
OX   NCBI_TaxID=1403948 {ECO:0000313|EMBL:ETI82812.1, ECO:0000313|Proteomes:UP000018843};
RN   [1] {ECO:0000313|EMBL:ETI82812.1, ECO:0000313|Proteomes:UP000018843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DORA_20 {ECO:0000313|Proteomes:UP000018843};
RA   Brown C.T., Sharon I., Thomas B.C., Castelle C.J., Morowitz M.J.,
RA   Banfield J.F.;
RT   "A Varibaculum cambriense genome reconstructed from a premature infant gut
RT   community with otherwise low bacterial novelty that shifts toward anaerobic
RT   metabolism during the third week of life.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETI82812.1}.
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DR   EMBL; AZMI01000001; ETI82812.1; -; Genomic_DNA.
DR   AlphaFoldDB; W1TMH8; -.
DR   STRING; 184870.HMPREF1862_00346; -.
DR   PATRIC; fig|1403948.3.peg.830; -.
DR   eggNOG; COG0612; Bacteria.
DR   Proteomes; UP000018843; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR11851:SF149; GH01077P; 1.
DR   PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018843}.
FT   DOMAIN          39..184
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          193..371
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   439 AA;  47105 MW;  0C16BEF6B9A30A20 CRC64;
     MPEKHDYKLP LSAQAPRLSI SEGETLIERS ILPGGIRLIT QQVPASPSVV LGFWIPAGSR
     DEGPQHLGST HYLEHLLFKG SATRTAKQIS RAFDAVGGEL NAATAKESTH YYCRVLSRDL
     PMAVEVLTEM LARPTLASPD FELERAVILD ELAMSQDDPQ DVGYENFLGQ LFPSSPLGLP
     VGGTAQTVAA TPLEAVKAHH QRWYQPRHLV VAAAGDIKHD RLAQLILEAA GKNGWDLPAG
     TDPEVPQRTQ PAPAVPASAV VEKTVEQGQI FIGTRSLPAN DPQRDTLSML LTVLSGGMSS
     RLFQEIREKR GLAYSTYAFD SAYSDSGSFG LYAGCAPNNL EQVGDLLVAE LEKLAEQGVP
     EGELSEALGQ LSGGVLLGMD DNRARMARLG RAEVNGGRLR TIEQLNAALQ NVSSAQISEL
     AAQFLGLPQV KVVVRPAVA
//