ID W1TRT0_9FIRM Unreviewed; 219 AA.
AC W1TRT0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=L-serine deaminase {ECO:0000256|PIRNR:PIRNR036692};
GN ORFNames=Q612_NSC00356G0002 {ECO:0000313|EMBL:ETI84337.1};
OS Negativicoccus succinicivorans DORA_17_25.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Negativicoccus.
OX NCBI_TaxID=1403945 {ECO:0000313|EMBL:ETI84337.1, ECO:0000313|Proteomes:UP000018840};
RN [1] {ECO:0000313|EMBL:ETI84337.1, ECO:0000313|Proteomes:UP000018840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DORA_17_25 {ECO:0000313|Proteomes:UP000018840};
RA Brown C.T., Sharon I., Thomas B.C., Castelle C.J., Morowitz M.J.,
RA Banfield J.F.;
RT "A Varibaculum cambriense genome reconstructed from a premature infant gut
RT community with otherwise low bacterial novelty that shifts toward anaerobic
RT metabolism during the third week of life.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169,
CC ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00001161,
CC ECO:0000256|PIRNR:PIRNR036692, ECO:0000256|RuleBase:RU366059};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966,
CC ECO:0000256|RuleBase:RU366059};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000256|ARBA:ARBA00004742, ECO:0000256|PIRNR:PIRNR036692}.
CC -!- SIMILARITY: Belongs to the iron-sulfur dependent L-serine dehydratase
CC family. {ECO:0000256|ARBA:ARBA00008636, ECO:0000256|PIRNR:PIRNR036692,
CC ECO:0000256|RuleBase:RU366059}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETI84337.1}.
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DR EMBL; AZMC01000356; ETI84337.1; -; Genomic_DNA.
DR AlphaFoldDB; W1TRT0; -.
DR PATRIC; fig|1403945.3.peg.1408; -.
DR UniPathway; UPA00138; -.
DR Proteomes; UP000018840; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003941; F:L-serine ammonia-lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniRule.
DR CDD; cd04903; ACT_LSD; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR029009; ASB_dom_sf.
DR InterPro; IPR004643; Fe-S_L-Ser_bsu.
DR InterPro; IPR005131; Ser_deHydtase_bsu.
DR NCBIfam; TIGR00719; sda_beta; 1.
DR PANTHER; PTHR30182; L-SERINE DEHYDRATASE; 1.
DR PANTHER; PTHR30182:SF12; L-SERINE DEHYDRATASE, BETA CHAIN-RELATED; 1.
DR Pfam; PF01842; ACT; 1.
DR Pfam; PF03315; SDH_beta; 1.
DR PIRSF; PIRSF036692; SDH_B; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF143548; Serine metabolism enzymes domain; 1.
DR PROSITE; PS51671; ACT; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|PIRNR:PIRNR036692, ECO:0000256|RuleBase:RU366059};
KW Gluconeogenesis {ECO:0000256|PIRNR:PIRNR036692,
KW ECO:0000256|RuleBase:RU366059};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRNR:PIRNR036692};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|PIRNR:PIRNR036692};
KW Lyase {ECO:0000256|PIRNR:PIRNR036692, ECO:0000256|RuleBase:RU366059};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR036692}.
FT DOMAIN 146..218
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 219 AA; 23703 MW; 16EC0429B1ED8F05 CRC64;
MGVFDIIGPV MIGPSSSHTA GAARLGRLAR YLLGESPIKA DITFYGSFAQ TYRGHGTDRA
CVAGLLNWAP DDQRLRDALT MAPELGLQVT ITASAAETEH PNTVRFHLTG SSGKARELMG
VSTGGGRIRM REFDGYSVDL DGSNHTLLTR HNDRPGIVAF VSQILAAQDI NISAMRLFRQ
ERKRLAMMFI ETDTPVANAT LAEIAAHPAI EVVRTFPPV
//
