ID   W1TS81_9ACTO            Unreviewed;       224 AA.
AC   W1TS81;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Shikimate kinase and 3-dehydroquinate synthase {ECO:0000313|EMBL:ETI83129.1};
GN   ORFNames=Q618_VCMC00001G0710 {ECO:0000313|EMBL:ETI83129.1};
OS   Varibaculum cambriense DORA_20.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Varibaculum.
OX   NCBI_TaxID=1403948 {ECO:0000313|EMBL:ETI83129.1, ECO:0000313|Proteomes:UP000018843};
RN   [1] {ECO:0000313|EMBL:ETI83129.1, ECO:0000313|Proteomes:UP000018843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DORA_20 {ECO:0000313|Proteomes:UP000018843};
RA   Brown C.T., Sharon I., Thomas B.C., Castelle C.J., Morowitz M.J.,
RA   Banfield J.F.;
RT   "A Varibaculum cambriense genome reconstructed from a premature infant gut
RT   community with otherwise low bacterial novelty that shifts toward anaerobic
RT   metabolism during the third week of life.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETI83129.1}.
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DR   EMBL; AZMI01000001; ETI83129.1; -; Genomic_DNA.
DR   AlphaFoldDB; W1TS81; -.
DR   STRING; 184870.HMPREF1862_01390; -.
DR   PATRIC; fig|1403948.3.peg.1158; -.
DR   eggNOG; COG0337; Bacteria.
DR   Proteomes; UP000018843; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd08195; DHQS; 1.
DR   Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR   InterPro; IPR030960; DHQS/DOIS.
DR   PANTHER; PTHR43622; 3-DEHYDROQUINATE SYNTHASE; 1.
DR   PANTHER; PTHR43622:SF7; 3-DEHYDROQUINATE SYNTHASE, CHLOROPLASTIC; 1.
DR   Pfam; PF01761; DHQ_synthase; 1.
DR   SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:ETI83129.1};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018843};
KW   Transferase {ECO:0000313|EMBL:ETI83129.1}.
FT   DOMAIN          1..170
FT                   /note="3-dehydroquinate synthase"
FT                   /evidence="ECO:0000259|Pfam:PF01761"
SQ   SEQUENCE   224 AA;  24070 MW;  2C17DD05E0333E42 CRC64;
     MGSFYPPSAV ICDLDYLQTL PPRQLHSGLA EVIKCGFIAD RKILQLLNGQ SPEKLVGSPA
     AAEEVISRAI NVKAGVVSED LREGGMRECL NYGHTLAHAI EKASSYQVLH GEAVAIGMVF
     AAQVAVELNL LTPSKMQSQR RQIAALGLPT TCPQYSFKQL LKIMASDKKV RGGVIRMVLT
     TGNGQIQVTP ITDYHLLERA FNAINQADTA AGSPSLSSQE PPSE
//