ID W1TU52_9ACTO Unreviewed; 469 AA.
AC W1TU52;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492};
GN ORFNames=Q618_VCMC00001G1390 {ECO:0000313|EMBL:ETI83809.1};
OS Varibaculum cambriense DORA_20.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Varibaculum.
OX NCBI_TaxID=1403948 {ECO:0000313|EMBL:ETI83809.1, ECO:0000313|Proteomes:UP000018843};
RN [1] {ECO:0000313|EMBL:ETI83809.1, ECO:0000313|Proteomes:UP000018843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DORA_20 {ECO:0000313|Proteomes:UP000018843};
RA Brown C.T., Sharon I., Thomas B.C., Castelle C.J., Morowitz M.J.,
RA Banfield J.F.;
RT "A Varibaculum cambriense genome reconstructed from a premature infant gut
RT community with otherwise low bacterial novelty that shifts toward anaerobic
RT metabolism during the third week of life.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|PIRNR:PIRNR036492,
CC ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETI83809.1}.
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DR EMBL; AZMI01000001; ETI83809.1; -; Genomic_DNA.
DR AlphaFoldDB; W1TU52; -.
DR STRING; 184870.HMPREF1862_00882; -.
DR PATRIC; fig|1403948.3.peg.428; -.
DR eggNOG; COG1012; Bacteria.
DR Proteomes; UP000018843; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR PANTHER; PTHR43570; ALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43570:SF16; ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q; 1.
DR Pfam; PF00171; Aldedh; 1.
DR PIRSF; PIRSF036492; ALDH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR036492};
KW Reference proteome {ECO:0000313|Proteomes:UP000018843}.
FT DOMAIN 3..440
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 215
FT /evidence="ECO:0000256|PIRSR:PIRSR036492-1,
FT ECO:0000256|PROSITE-ProRule:PRU10007"
FT ACT_SITE 249
FT /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
SQ SEQUENCE 469 AA; 52238 MW; 54F599911FB312C3 CRC64;
MSSSQEQAIR RAVESARSCF NAGTTIPISG RQKNLTALLR EIEKSRTEIY SALKQDLNKS
RTEAYMSEIS LVKAEIRHLR RRLPWLAMPR SKLPALSQLP GWLQVQREPY GVVLVMSPWN
YPFQLTMEPI AAAIAGGNTV VVKPSAYTPH TCEVIEKILR RALPPGMASV IRGGRAENTA
LLEQRFDHIF FTGSPAVGRV VMEAASRYLT PVTLELGGKS PCFVDRTADI EKAARRILFG
KLLNAGQTCV SVDYVYVHED VREQLIAALQ AGIARALPSE QYRKSAFVKI ISPKHFSRLS
GLLAEQRLLG AKGGGHAEDF LDRQTQQIKP VIVDNPSWDS PVMSEEIFGP ILPVLPFTDL
EATLADYEER EHPLALYIFT KDRGFARQVM SKVNAGGVCI NDTLLHMSSS KAPFGGVGNS
GMGNYHGDWS FKAMTREQTV LRKSWLFDIP VRHHPYGEKS LKILRSLLR
//
