ID W2BWQ6_9FIRM Unreviewed; 1186 AA.
AC W2BWQ6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Chromosome partition protein Smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN Name=smc {ECO:0000256|HAMAP-Rule:MF_01894,
GN ECO:0000313|EMBL:ETJ99252.1};
GN ORFNames=HMPREF0378_0629 {ECO:0000313|EMBL:ETJ99252.1};
OS Eubacterium nodatum ATCC 33099.
OC Bacteria; Bacillota; Clostridia; Eubacteriales;
OC Eubacteriales Family XIII. Incertae Sedis.
OX NCBI_TaxID=1161902 {ECO:0000313|EMBL:ETJ99252.1, ECO:0000313|Proteomes:UP000018868};
RN [1] {ECO:0000313|EMBL:ETJ99252.1, ECO:0000313|Proteomes:UP000018868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33099 {ECO:0000313|EMBL:ETJ99252.1,
RC ECO:0000313|Proteomes:UP000018868};
RA Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA Methe B., Sutton G., Nelson K.E.;
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for chromosome condensation and partitioning.
CC {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- DOMAIN: Contains large globular domains required for ATP hydrolysis at
CC each terminus and a third globular domain forming a flexible hinge near
CC the middle of the molecule. These domains are separated by coiled-coil
CC structures. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005917}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETJ99252.1}.
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DR EMBL; AZKM01000024; ETJ99252.1; -; Genomic_DNA.
DR AlphaFoldDB; W2BWQ6; -.
DR STRING; 1161902.HMPREF0378_0629; -.
DR PATRIC; fig|1161902.3.peg.1308; -.
DR eggNOG; COG1196; Bacteria.
DR OrthoDB; 9808768at2; -.
DR Proteomes; UP000018868; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030261; P:chromosome condensation; IEA:InterPro.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd03278; ABC_SMC_barmotin; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01894; Smc_prok; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR011890; SMC_prok.
DR NCBIfam; TIGR02168; SMC_prok_B; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR PANTHER; PTHR43977:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_01894};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01894};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Reference proteome {ECO:0000313|Proteomes:UP000018868}.
FT DOMAIN 519..636
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT COILED 248..289
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 332..359
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 409..471
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 776..845
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 1000..1049
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
SQ SEQUENCE 1186 AA; 135429 MW; FAAFD47AC5602FA2 CRC64;
MYFKRLEMHG FKSFAEPVII DFHEGITCIV GPNGSGKSNI SDAVRWVLGE QSPKALRGGK
MEEVIFNGTE SRRPRGMAEV TLVIDNSTGI LDIEYKEVAI TRRMFRSGES EYLINDNPCR
LKDIRELIMD TGIGVDGYSI IGQGKISDIV SNKPESRREI FEEAAGIVAY KTRKQETERK
LIGTKNNLER IDDIVGEIEG RIGGLKEDSI KAKRYLELKE HYKDLEINII LRNIESTLHK
NNEYSGDISE LGNKLDSINR QRKQADESFQ ELQKRNGVLE ELSSDLNRKL IENKDKMNSI
SSESRLNHEK LLHLRKEEER LSGEVSNFAE LIAAGEKELE HLRVELTEID ENLAAAEKRL
QEKIYLYDSV TGESSKFSDI IDENNEKIIS LNSEAASKKS EAKSYKSYQY TLEDRKEKLQ
TELEKLKENQ TKSTFDLGEK KKEIERLQGL QNEIKEKIQS QLENRQKLEQ EELYFRRKLE
ELKISQSRTE TRLHTIEEME QNFEGYNYAV KYIMRCGISG IEGVVGEMIN VPEGYETAVE
TALGAAMQNI VVADDDCAKK AITALKVSQS GRLTFLPVGS INSKKAVLDG SITSDHGFCG
IGSELIDFEP RYKKIFDYLL GRVVIVKDLN SAILLSKRGS NGVRFVTLDG EVINSGGAIT
GGRYKNKSAN LLERKNEISK LKNLLHSQEI GIDETSKKLN EKKDALSEMI RISKEDVERI
RKCEISIARV KDGITYLENV IADIKLNAEK NEKEIIQIDR DLSEMSDVIL KFDEESRAAQ
SEIEKIGKEM DEILQKHQKN KKAIEFANQG ITEARIDVNL WEEKRNNLNG NIEKNKEAVE
RLRVRSEEQV DKLSDIREDK GKLEQGTGGS NMQLERLKVK LLELQEDIEK VSLEKSEVGV
KLGELGNEIT RTDRESNLYR DQKYQLEIKK AKNDTQLDNM KDKLWNEFEI SYAQAGDLRK
EEFAMSSAVK ESREIRKELK EIGDVNVGAI EEYKQVSKRY EFLTEQREDI LKAMEELEDL
VNNLDKTIMR SFKENFNKVE ENFENVFEEL FGGGYAELRM ENENNPLESG IEIVAQPPGK
KLQNINLMSG GEKTMTAIAL MFAVLKTKPT PFCILDEIEA ALDDKNIDKF SHYLRKFAET
QFALITHQKA TMEHADVLYG ITMPERGISK VLSLRMGDYD PDEYTS
//
