ID W2CQ21_9BACT Unreviewed; 429 AA.
AC W2CQ21;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=inositol-3-phosphate synthase {ECO:0000256|ARBA:ARBA00012125};
DE EC=5.5.1.4 {ECO:0000256|ARBA:ARBA00012125};
GN ORFNames=T230_05125 {ECO:0000313|EMBL:ETK09270.1};
OS Tannerella sp. oral taxon BU063 isolate Cell 1/3.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
OC Tannerella.
OX NCBI_TaxID=1411022 {ECO:0000313|EMBL:ETK09270.1, ECO:0000313|Proteomes:UP000034982};
RN [1] {ECO:0000313|EMBL:ETK09270.1, ECO:0000313|Proteomes:UP000034982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cell 1/3 {ECO:0000313|EMBL:ETK09270.1};
RA Beall C.J., Campbell A.G., Griffen A.L., Podar M., Leys E.J.;
RT "Single cell genomics of uncultured Tannerella BU063 (oral taxon 286).";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC from D-glucose 6-phosphate: step 1/2. {ECO:0000256|ARBA:ARBA00005117}.
CC -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC {ECO:0000256|ARBA:ARBA00010813}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETK09270.1}.
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DR EMBL; AYYE01000844; ETK09270.1; -; Genomic_DNA.
DR AlphaFoldDB; W2CQ21; -.
DR PATRIC; fig|1411022.3.peg.374; -.
DR Proteomes; UP000034982; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:InterPro.
DR GO; GO:0006021; P:inositol biosynthetic process; IEA:InterPro.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11510:SF5; INOSITOL-3-PHOSPHATE SYNTHASE 1; 1.
DR PANTHER; PTHR11510; MYO-INOSITOL-1 PHOSPHATE SYNTHASE; 1.
DR Pfam; PF01658; Inos-1-P_synth; 1.
DR Pfam; PF07994; NAD_binding_5; 1.
DR PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 245..357
FT /note="Myo-inositol-1-phosphate synthase GAPDH-like"
FT /evidence="ECO:0000259|Pfam:PF01658"
SQ SEQUENCE 429 AA; 47865 MW; 5696B6CBC5DCD398 CRC64;
MIQELKAADG RLAVLIAGVG GAVSTTMIAG VMAARRGLAK PIGSVTQMGR MRRQDGCEQL
IKEMVPIAEL DSLVFGGWDI FPDNALEAAR CAEVLSEKDL KGVADELATI RPMAAAFDPR
WAKRLHGTHT LQGATRREMI EHLRGDIRRF MADNKCSRAV VLWAASTEIF LPMTDEHRSL
ESLDRAIDAN NTEVISPSMC YAYAALSEGV PFIMGAPNLC VDIPAMWELA AQKHVPIAGK
DFKSGQTLMK TVLAPMFKTR LLGVSGWFST NILGNRDGEV LDDPDNFKTK EVSKLSVIES
ILDADEQPDL YKDIYHKVRI NYYPPRKDNK EAWDNIDLFG WMGYPMEIKV NFLCRDSILA
APIALDLVLF SDLAARAGMS GIQTWLSFFC KSPMHDFDHV PEHDLFTQWR IVKQTLRTLV
GEREPDYLS
//
