ID   W2EHB0_9ACTN            Unreviewed;       814 AA.
AC   W2EHB0;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   RecName: Full=HTH luxR-type domain-containing protein {ECO:0000259|PROSITE:PS50043};
GN   ORFNames=MPTA5024_36740 {ECO:0000313|EMBL:ETK31075.1};
OS   Microbispora sp. ATCC PTA-5024.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Microbispora.
OX   NCBI_TaxID=316330 {ECO:0000313|EMBL:ETK31075.1, ECO:0000313|Proteomes:UP000018869};
RN   [1] {ECO:0000313|EMBL:ETK31075.1, ECO:0000313|Proteomes:UP000018869}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PTA-5024 {ECO:0000313|EMBL:ETK31075.1,
RC   ECO:0000313|Proteomes:UP000018869};
RX   PubMed=24459268;
RA   Sosio M., Gallo G., Pozzi R., Serina S., Monciardini P., Bera A.,
RA   Stegmann E., Weber T.;
RT   "Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024,
RT   Producing the Lantibiotic NAI-107.";
RL   Genome Announc. 2:e01198-13(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETK31075.1}.
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DR   EMBL; AWEV01000295; ETK31075.1; -; Genomic_DNA.
DR   RefSeq; WP_051459071.1; NZ_KI866527.1.
DR   AlphaFoldDB; W2EHB0; -.
DR   STRING; 316330.MPTA5024_36740; -.
DR   PATRIC; fig|316330.3.peg.7070; -.
DR   HOGENOM; CLU_004665_5_3_11; -.
DR   Proteomes; UP000018869; Unassembled WGS sequence.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR   PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018869}.
FT   DOMAIN          729..794
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50043"
FT   REGION          695..738
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          794..814
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        796..814
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   814 AA;  88825 MW;  90215AD33615A1D0 CRC64;
     MAIPAALVRQ IGNLPADLTS FVGRRRELAE IRRLLSVSRL VTLTGVGGVG KTRLALRAAA
     EQHRAFDAVW LVDLTALDDP ALVAETVAAT LGVQSEINPV DALARVLTGR RTLLVLDNCE
     HLRDACASFA NRLLRAVPDL RILATSRQSL GIIGEHQMRV APLALPEPGR PLTGRALELY
     DGVSLFLERA SAVVPGFRLT PDIAADVVEL CRRLDGIPLA IELAAVRLRA LSVGTLVERL
     TDRYACLTSG SRTVAPRQRT LHALVDWSYQ LLSPAERTLW SRMSVFPGHF DLKAVEDVCA
     CGDVEPEDVL DLIDALLDKS LLLREEHHGE VRFRMLETLR EFGRLRLDGP DERRSLARRH
     RDHYLALLER AAGEWFGPAQ AGWFARLRLE QAHLRGALEF CLHERGEADV GLLMAALLYE
     TYWLPNAFYS EGRHWFDLLL KSAPAPTAVR AEALCADAQM AFIQGDTAVA ELLVGEGLAL
     AEKLGHAKSL ALGSLVSGIA AHQHGDYARA AVLLEEAVTG HTAAGDGLAA LVGLLTLAAT
     AGSLGEEDRE RRLFERSLAL AESGGDSWIR SWVLTVAAVH AWQRGDAERA TDLARESLVV
     GRDFDDRLAL ATTFEVLGWI FETGRRDASA ARMLGVAEEL CRAAGASIQR VASYSESHER
     CVIALRERMG ERSFDRALRQ GERLTLDDAV AEALGSRLDE RPDEGPGAEP DEGPDEMFGE
     GRPGRGERAG PEPSPLTGRE REIAELISQG LSNKEISSAL VIAQRTTEGH VEHILTKLGF
     SSRTQIAAWV AARKAAGGHT RDHDAIPRRP RRTR
//