ID   W2EJN5_9ACTN            Unreviewed;       749 AA.
AC   W2EJN5;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   13-SEP-2023, entry version 34.
DE   RecName: Full=HTH cro/C1-type domain-containing protein {ECO:0000259|PROSITE:PS50943};
GN   ORFNames=MPTA5024_32415 {ECO:0000313|EMBL:ETK31913.1};
OS   Microbispora sp. ATCC PTA-5024.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Microbispora.
OX   NCBI_TaxID=316330 {ECO:0000313|EMBL:ETK31913.1, ECO:0000313|Proteomes:UP000018869};
RN   [1] {ECO:0000313|EMBL:ETK31913.1, ECO:0000313|Proteomes:UP000018869}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PTA-5024 {ECO:0000313|EMBL:ETK31913.1,
RC   ECO:0000313|Proteomes:UP000018869};
RX   PubMed=24459268;
RA   Sosio M., Gallo G., Pozzi R., Serina S., Monciardini P., Bera A.,
RA   Stegmann E., Weber T.;
RT   "Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024,
RT   Producing the Lantibiotic NAI-107.";
RL   Genome Announc. 2:e01198-13(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETK31913.1}.
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DR   EMBL; AWEV01000263; ETK31913.1; -; Genomic_DNA.
DR   RefSeq; WP_051458905.1; NZ_KI866526.1.
DR   AlphaFoldDB; W2EJN5; -.
DR   STRING; 316330.MPTA5024_32415; -.
DR   PATRIC; fig|316330.3.peg.6247; -.
DR   HOGENOM; CLU_004665_2_1_11; -.
DR   OrthoDB; 5521887at2; -.
DR   Proteomes; UP000018869; Unassembled WGS sequence.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR   PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR   Pfam; PF13560; HTH_31; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF13374; TPR_10; 1.
DR   Pfam; PF13424; TPR_12; 2.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SMART; SM00028; TPR; 5.
DR   SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018869};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          14..68
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50943"
FT   REPEAT          543..576
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   749 AA;  80131 MW;  2FDDA2D122A612EA CRC64;
     MIGSTRCGDF GSELRRLRTA RGLSLTALAR QVNYTKGYLS KIESGRRPPN AEVARRCDAA
     LNASGHLIGL VKPPGSPSRD SGTPPRQIPP VAAGFVGRQV ESERLDSLTA LPVTAETPPA
     VVITGPAGVG KSTLAYWWAR RRIDRFPDGV LVANLRGFGP AERPADPSGV LEGLLRSLGV
     LPHAIPASLD ERAAALRTAL SGRRMLIVLD DAAGPEQVRP LLTGSPLCRT IVTSRTTMSG
     LVARDGAVRL PVGPLPSGDS WALLRSAVGD DRIQAGDEAA ERIVRACAGL PLALRIAAER
     LARLPDSQLA ALADELSGGG RRLDLLRADD DDAATVPAVL LWSYERLPPD AARLFRLVGT
     LTTADIGEAA AAALLDVTRE KAGRALGELA GIHLLEPSGG GRYRMHDLVR EFAAGLAEER
     DSSSGRTEAV GRLATWYVHA LAAADRVLMP HRPNADPGPA PAGLDVPEFA GHAEAMAWCE
     AERVNVAPVV RMAGDHGLDE PAWQLAALVS GFYMQSKYWS EWREATEAGL RSARRAGDLA
     GEARLLNSLG VIHGDLRRYE ESLECFERVV DIRRRLGDRR GEAAALTNVS SVNHRMGRPG
     RSMKLLTAVL AIDRELGNEY GEAVTRTNLG AAALDLKRYD EALGHFETGL AILHRLGNRY
     AEGMALDSIG KLHAAMGDYE KAARSHRAAL AIFREIEDRH NEAGSLHLLG TALLNAGHGQ
     EARRVLRSAL AIFERSGAPE AEEVRALLS
//