ID W2ELT9_9ACTN Unreviewed; 775 AA.
AC W2ELT9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=RNA polymerase sigma factor {ECO:0000256|RuleBase:RU000716};
GN ORFNames=MPTA5024_28690 {ECO:0000313|EMBL:ETK32623.1};
OS Microbispora sp. ATCC PTA-5024.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Microbispora.
OX NCBI_TaxID=316330 {ECO:0000313|EMBL:ETK32623.1, ECO:0000313|Proteomes:UP000018869};
RN [1] {ECO:0000313|EMBL:ETK32623.1, ECO:0000313|Proteomes:UP000018869}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC PTA-5024 {ECO:0000313|EMBL:ETK32623.1,
RC ECO:0000313|Proteomes:UP000018869};
RX PubMed=24459268;
RA Sosio M., Gallo G., Pozzi R., Serina S., Monciardini P., Bera A.,
RA Stegmann E., Weber T.;
RT "Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024,
RT Producing the Lantibiotic NAI-107.";
RL Genome Announc. 2:e01198-13(2014).
CC -!- SIMILARITY: Belongs to the sigma-70 factor family. ECF subfamily.
CC {ECO:0000256|ARBA:ARBA00010641, ECO:0000256|RuleBase:RU000716}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETK32623.1}.
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DR EMBL; AWEV01000224; ETK32623.1; -; Genomic_DNA.
DR AlphaFoldDB; W2ELT9; -.
DR STRING; 316330.MPTA5024_28690; -.
DR PATRIC; fig|316330.3.peg.5535; -.
DR HOGENOM; CLU_417781_0_0_11; -.
DR Proteomes; UP000018869; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR GO; GO:0006950; P:response to stress; IEA:UniProt.
DR CDD; cd00397; DNA_BRE_C; 1.
DR Gene3D; 1.10.1740.10; -; 1.
DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR046531; DUF6596.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR InterPro; IPR000838; RNA_pol_sigma70_ECF_CS.
DR InterPro; IPR007627; RNA_pol_sigma70_r2.
DR InterPro; IPR013249; RNA_pol_sigma70_r4_t2.
DR InterPro; IPR013325; RNA_pol_sigma_r2.
DR InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR02937; sigma70-ECF; 1.
DR PANTHER; PTHR47756:SF1; BLL0085 PROTEIN; 1.
DR PANTHER; PTHR47756; BLL6612 PROTEIN-RELATED; 1.
DR Pfam; PF20239; DUF6596; 1.
DR Pfam; PF02899; Phage_int_SAM_1; 1.
DR Pfam; PF04542; Sigma70_r2; 1.
DR Pfam; PF08281; Sigma70_r4_2; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF88946; Sigma2 domain of RNA polymerase sigma factors; 1.
DR SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS01063; SIGMA70_ECF; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01248}; Reference proteome {ECO:0000313|Proteomes:UP000018869};
KW Sigma factor {ECO:0000256|RuleBase:RU000716};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU000716};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU000716}.
FT DOMAIN 474..553
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000259|PROSITE:PS51900"
FT DOMAIN 576..775
FT /note="Tyr recombinase"
FT /evidence="ECO:0000259|PROSITE:PS51898"
FT REGION 427..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 775 AA; 83621 MW; 8A63C7C5D0939558 CRC64;
MTSWDAHRAV DAVWKLEAAR IVAGLVRMTG DVGLAEELAQ DALLAALERW PESGVPENPG
AWLMAVAKRR AVDRLRRDER LDRRHEQLAH ELATRRHPLD GDEDLDAALG AVDGEVGDDV
LRLMFISCHP VLSTESRVAL TLRLVGGLRT DEIARAFLVS EPTVAQRIVR AKRTLAAERI
PFEVPEGPDR ASRLSSVLEV VYLIFNEGYA ATSGDDWTRP SLGLEALRLG RVLAGLAPGE
AEVHGLVALM ELQQSRSAAR TGPSGEPVQL HEQNRGRWDQ LLIRRGFASL LRAREAGGPL
GPYVLQAAIA ACHAGARTAE ETDWGRIAAL YEALVRVLPT PVVRLNQAVA VAMARGPREG
LALADTLTAE PAMKGYHLLP VVRGDLLSRL GRHDEARAEF ERAASLTRNV PERAILLARA
SASAAASPAA PAADDDGAAP HAAPHAAPHA AADAAAAGRT GTRAVAAVPA RSGVTLAEAV
RAFLDRPALN DETVRSYGQT MTRLRRHLGD DAILAEVTAD EVGAAFAAAW GTAAAATWNR
HRAAVRSFAA WAAGPERGWT ADDLAARLDR RPEPRGRTRP MGRRQVEALL EREEVPLRER
TLWTLLYESA ATAEWVLALN VEDLDLSGRY GRIPARTAHS PESGESDGNG GNGGGAGERR
VRWQSGAARL LPGLVAGRRR GPLFLADRRP GPARTPAAGD LCPHTGRGRL SYERAEYLFK
RATRDLDPDG NGYTLRLLRH SRLAHLGEDG WSAGMLRDLS GHDSLRTLAP YVRSR
//
