ID W2EQA6_9ACTN Unreviewed; 331 AA.
AC W2EQA6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:ETK33116.1};
GN ORFNames=MPTA5024_26310 {ECO:0000313|EMBL:ETK33116.1};
OS Microbispora sp. ATCC PTA-5024.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Microbispora.
OX NCBI_TaxID=316330 {ECO:0000313|EMBL:ETK33116.1, ECO:0000313|Proteomes:UP000018869};
RN [1] {ECO:0000313|EMBL:ETK33116.1, ECO:0000313|Proteomes:UP000018869}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC PTA-5024 {ECO:0000313|EMBL:ETK33116.1,
RC ECO:0000313|Proteomes:UP000018869};
RX PubMed=24459268;
RA Sosio M., Gallo G., Pozzi R., Serina S., Monciardini P., Bera A.,
RA Stegmann E., Weber T.;
RT "Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024,
RT Producing the Lantibiotic NAI-107.";
RL Genome Announc. 2:e01198-13(2014).
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETK33116.1}.
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DR EMBL; AWEV01000203; ETK33116.1; -; Genomic_DNA.
DR AlphaFoldDB; W2EQA6; -.
DR STRING; 316330.MPTA5024_26310; -.
DR PATRIC; fig|316330.3.peg.5073; -.
DR HOGENOM; CLU_026673_3_3_11; -.
DR OrthoDB; 2665481at2; -.
DR Proteomes; UP000018869; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08272; MDR6; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR PANTHER; PTHR44154; QUINONE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR44154:SF1; QUINONE OXIDOREDUCTASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018869};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 10..324
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 331 AA; 33628 MW; 884A62939429BDD9 CRC64;
MRALVLEAYG QPLRPAAVTR PAPGAGEVLV RVGASGVNPL DIKIRNGQAA HARVSPPAVL
GIDVAGVVEA VGAGVTGFAP GDEVYGMTGG VGGVQGSLAE FASVDARLLA PKPAALTMRE
AAALPLIVIT AWEGLVDRAR VRAGQKVLVH GGAGGVGQAA VQIARARGAE VYATGSARSL
GAIERLGATA IDYAATPVER YVAAYTDGEG FDIVVDTVGG ATLDASFSAV RTYEGHVVSS
LGWGAHSLAP LSFRGATYSG VFTLLPLLTG RGREHHGEIL REVAALADSG ALRPILDPRR
FTLETVEEAH KAVASGDAAG KVVVEVVPAI T
//
