ID W2EWF9_9ACTN Unreviewed; 383 AA.
AC W2EWF9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:ETK35311.1};
GN ORFNames=MPTA5024_14770 {ECO:0000313|EMBL:ETK35311.1};
OS Microbispora sp. ATCC PTA-5024.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Microbispora.
OX NCBI_TaxID=316330 {ECO:0000313|EMBL:ETK35311.1, ECO:0000313|Proteomes:UP000018869};
RN [1] {ECO:0000313|EMBL:ETK35311.1, ECO:0000313|Proteomes:UP000018869}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC PTA-5024 {ECO:0000313|EMBL:ETK35311.1,
RC ECO:0000313|Proteomes:UP000018869};
RX PubMed=24459268;
RA Sosio M., Gallo G., Pozzi R., Serina S., Monciardini P., Bera A.,
RA Stegmann E., Weber T.;
RT "Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024,
RT Producing the Lantibiotic NAI-107.";
RL Genome Announc. 2:e01198-13(2014).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETK35311.1}.
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DR EMBL; AWEV01000108; ETK35311.1; -; Genomic_DNA.
DR RefSeq; WP_036324498.1; NZ_KI866523.1.
DR AlphaFoldDB; W2EWF9; -.
DR STRING; 316330.MPTA5024_14770; -.
DR PATRIC; fig|316330.3.peg.2862; -.
DR HOGENOM; CLU_026673_11_3_11; -.
DR OrthoDB; 241504at2; -.
DR Proteomes; UP000018869; Unassembled WGS sequence.
DR CDD; cd08282; PFDH_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42813:SF3; GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018869}.
FT DOMAIN 25..136
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 188..291
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 383 AA; 41508 MW; 0615FA5FD2D222EA CRC64;
MKAVVYKGPR QLDVENVPDA RIEMPTDVLV RVTTTNICGS DLHMYEGRTD LEPGRVLGHE
NLGEVVEVGP GVVNVRVGDL VCLPFNVACG FCANCEKGLT AFCLTTNPQM GVDGAAYGFA
DMGPYNGGQA ELLRVPFGDF NCLVLPDDAR ERQTDYVMLA DIWPTGWHAT QLACVQAGDS
VVIYGAGPVG LMAAYSATFK SASMVMVVDR HPDRLAKAEE IGAIPIDDSK SSPVDQVMEL
TQGRGADRGC ECVGYQAHDP QGHEHPNMTL NNLVKSVRFA GTIGVVGVFI PMDPGSPDDL
YKQGEIAFDY GMFWFKGQTM GNGQCNVKNY NRQLCTLIHK GKARPSWVVS HELDLDDAPG
GYEHFDRRDP GWTKVVLHPA GVG
//
