ID W2EY10_9ACTN Unreviewed; 365 AA.
AC W2EY10;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 08-NOV-2023, entry version 34.
DE SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:ETK36555.1};
GN ORFNames=MPTA5024_08535 {ECO:0000313|EMBL:ETK36555.1};
OS Microbispora sp. ATCC PTA-5024.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Microbispora.
OX NCBI_TaxID=316330 {ECO:0000313|EMBL:ETK36555.1, ECO:0000313|Proteomes:UP000018869};
RN [1] {ECO:0000313|EMBL:ETK36555.1, ECO:0000313|Proteomes:UP000018869}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC PTA-5024 {ECO:0000313|EMBL:ETK36555.1,
RC ECO:0000313|Proteomes:UP000018869};
RX PubMed=24459268;
RA Sosio M., Gallo G., Pozzi R., Serina S., Monciardini P., Bera A.,
RA Stegmann E., Weber T.;
RT "Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024,
RT Producing the Lantibiotic NAI-107.";
RL Genome Announc. 2:e01198-13(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETK36555.1}.
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DR EMBL; AWEV01000072; ETK36555.1; -; Genomic_DNA.
DR RefSeq; WP_036321216.1; NZ_KI866522.1.
DR AlphaFoldDB; W2EY10; -.
DR STRING; 316330.MPTA5024_08535; -.
DR PATRIC; fig|316330.3.peg.1653; -.
DR HOGENOM; CLU_055968_1_1_11; -.
DR OrthoDB; 9802008at2; -.
DR Proteomes; UP000018869; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR046826; PDH_N.
DR InterPro; IPR003099; Prephen_DH.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF20463; PDH_C; 1.
DR Pfam; PF02153; PDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000018869};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..291
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 365 AA; 37211 MW; BA5A902A0E0C0101 CRC64;
MTPIEDAAIG SVVVVGTGLI GTSIALALRQ RDVRVFLADR DPAAVRIARE LGAGEDWTGG
RRADLAVVAV PPQFVAQQLL DLQKRDAARV YTDVASVKVL PLAQAAQLGC DLTAYVAGHP
LAGRERSGPA AARADLFLGR PWAYCPTPEA APEAVAAVEG LIALCGGNAV RVDAGEHDRA
VAVVSHAPHV TAAAVAARLA EAPDAALGLS GQGVRDVTRI AASDPALWTG ILSGNAIPVA
EVLEAVVADL SAAARALRAL AGDGNAVGDV TDLLSRGVAG TSRIPGKHGG PARTYAVVQV
VIGDRPGELA RLVQAAGETG VNIEDIRLEH APGLPVGAAE LYVQPEAAAA LTEGLRERGW
QVPTS
//
