ID W2F419_9ACTN Unreviewed; 599 AA.
AC W2F419;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Histidine kinase {ECO:0000313|EMBL:ETK38006.1};
GN ORFNames=MPTA5024_01270 {ECO:0000313|EMBL:ETK38006.1};
OS Microbispora sp. ATCC PTA-5024.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Microbispora.
OX NCBI_TaxID=316330 {ECO:0000313|EMBL:ETK38006.1, ECO:0000313|Proteomes:UP000018869};
RN [1] {ECO:0000313|EMBL:ETK38006.1, ECO:0000313|Proteomes:UP000018869}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC PTA-5024 {ECO:0000313|EMBL:ETK38006.1,
RC ECO:0000313|Proteomes:UP000018869};
RX PubMed=24459268;
RA Sosio M., Gallo G., Pozzi R., Serina S., Monciardini P., Bera A.,
RA Stegmann E., Weber T.;
RT "Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024,
RT Producing the Lantibiotic NAI-107.";
RL Genome Announc. 2:e01198-13(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETK38006.1}.
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DR EMBL; AWEV01000015; ETK38006.1; -; Genomic_DNA.
DR RefSeq; WP_036318852.1; NZ_KI866522.1.
DR AlphaFoldDB; W2F419; -.
DR STRING; 316330.MPTA5024_01270; -.
DR PATRIC; fig|316330.3.peg.244; -.
DR HOGENOM; CLU_034370_1_0_11; -.
DR OrthoDB; 5241249at2; -.
DR Proteomes; UP000018869; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF56; OXYGEN SENSOR HISTIDINE KINASE RESPONSE REGULATOR DOST; 1.
DR Pfam; PF13185; GAF_2; 2.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR SMART; SM00065; GAF; 2.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ETK38006.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018869};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 51..198
FT /note="GAF"
FT /evidence="ECO:0000259|SMART:SM00065"
FT DOMAIN 219..397
FT /note="GAF"
FT /evidence="ECO:0000259|SMART:SM00065"
FT DOMAIN 509..599
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|SMART:SM00387"
FT REGION 274..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 599 AA; 63951 MW; 4ACD2A9F2A3B91F6 CRC64;
MTDHEPRVLV PHMRLDELLS ELQTRLEAVL ATRDRVHALL EAVVSIGSDL DLETVLRRIV
ETATTLVDAS YGAMGVIGEE NTLVQFVPVG LSEEEIARIE HWPHGLGLLG LLIKEPQTLR
LSHISQHPES YGFPPGHPPM GSFLGVPVRV RDEVFGNLYL TEKRGGGEFD EEDEAIVVAL
ATAAGVAVEN ARLYEASRRR ETWLQASSEI TTRLLSGADP QEVLRLIAHR AREMADADAA
VILLPGPDDT LQPVLEDGAS LRVPAEAGTT GGAEAVVSDG LGEPGAGATG AGSGDERAAR
TVPVEGSLAG RAFLRGEPLM VDDPAGSDLL LAFGEGFSLG PVAAVPLGAP GAVRGVLSLV
KRPGRMPFST SELRMLHAFS GQAAVALELA EARKDAERLG LLEDRDRIAK DLHDVVIQRL
FAVAMTLMSA VRLVERPEAS SRLQTAIDEL DTTIRQIRST IFALQTPREE SAPSLRSQIV
DLVENARGHL GFMPGLSLEG RLDSEVPEPV AEHLLAVLRE ALSNLVRHAM ASRADVTVRA
GDGRLTLVVR DDGVGVPETG RRSGLRNLAD RAEGLGGAFE VTAPEGGGTR LEWSVPLDV
//
