ID W2GCA0_PHYPR Unreviewed; 317 AA.
AC W2GCA0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Presenilin {ECO:0008006|Google:ProtNLM};
GN ORFNames=L914_14144 {ECO:0000313|EMBL:ETM39706.1}, L915_14322
GN {ECO:0000313|EMBL:ETK79836.1}, L916_14227
GN {ECO:0000313|EMBL:ETL33254.1}, L917_14018
GN {ECO:0000313|EMBL:ETL86541.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETK79836.1};
RN [1] {ECO:0000313|EMBL:ETL86541.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHvinca01 {ECO:0000313|EMBL:ETL86541.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CHvinca01.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETK79836.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ02B3 {ECO:0000313|EMBL:ETK79836.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ02B3.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETL33254.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ05E6 {ECO:0000313|EMBL:ETL33254.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ05E6.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ETM39706.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAC_01/95 {ECO:0000313|EMBL:ETM39706.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica IAC_01/95.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase A22A family.
CC {ECO:0000256|ARBA:ARBA00008604}.
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DR EMBL; KI687785; ETK79835.1; -; Genomic_DNA.
DR EMBL; KI687785; ETK79836.1; -; Genomic_DNA.
DR EMBL; KI687785; ETK79837.1; -; Genomic_DNA.
DR EMBL; KI687785; ETK79838.1; -; Genomic_DNA.
DR EMBL; KI674543; ETL33254.1; -; Genomic_DNA.
DR EMBL; KI674543; ETL33255.1; -; Genomic_DNA.
DR EMBL; KI674543; ETL33256.1; -; Genomic_DNA.
DR EMBL; KI674543; ETL33257.1; -; Genomic_DNA.
DR EMBL; KI681222; ETL86541.1; -; Genomic_DNA.
DR EMBL; KI681222; ETL86542.1; -; Genomic_DNA.
DR EMBL; KI681222; ETL86543.1; -; Genomic_DNA.
DR EMBL; KI681222; ETL86544.1; -; Genomic_DNA.
DR EMBL; KI694475; ETM39706.1; -; Genomic_DNA.
DR EMBL; KI694475; ETM39707.1; -; Genomic_DNA.
DR EMBL; KI694475; ETM39708.1; -; Genomic_DNA.
DR EMBL; KI694475; ETM39709.1; -; Genomic_DNA.
DR EnsemblProtists; ETK79835; ETK79835; L915_14322.
DR EnsemblProtists; ETK79836; ETK79836; L915_14322.
DR EnsemblProtists; ETK79837; ETK79837; L915_14322.
DR EnsemblProtists; ETK79838; ETK79838; L915_14322.
DR EnsemblProtists; ETL33254; ETL33254; L916_14227.
DR EnsemblProtists; ETL33255; ETL33255; L916_14227.
DR EnsemblProtists; ETL33256; ETL33256; L916_14227.
DR EnsemblProtists; ETL33257; ETL33257; L916_14227.
DR EnsemblProtists; ETL86541; ETL86541; L917_14018.
DR EnsemblProtists; ETL86542; ETL86542; L917_14018.
DR EnsemblProtists; ETL86543; ETL86543; L917_14018.
DR EnsemblProtists; ETL86544; ETL86544; L917_14018.
DR EnsemblProtists; ETM39706; ETM39706; L914_14144.
DR EnsemblProtists; ETM39707; ETM39707; L914_14144.
DR EnsemblProtists; ETM39708; ETM39708; L914_14144.
DR EnsemblProtists; ETM39709; ETM39709; L914_14144.
DR VEuPathDB; FungiDB:PPTG_15131; -.
DR Proteomes; UP000053236; Unassembled WGS sequence.
DR Proteomes; UP000053864; Unassembled WGS sequence.
DR Proteomes; UP000054423; Unassembled WGS sequence.
DR Proteomes; UP000054532; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 1.10.472.100; Presenilin; 1.
DR InterPro; IPR001108; Peptidase_A22A.
DR InterPro; IPR006639; Preselin/SPP.
DR InterPro; IPR042524; Presenilin_C.
DR PANTHER; PTHR10202; PRESENILIN; 1.
DR PANTHER; PTHR10202:SF13; PRESENILIN-2; 1.
DR Pfam; PF01080; Presenilin; 1.
DR SMART; SM00730; PSN; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 317 AA; 35649 MW; 2ACA659CFE4432A2 CRC64;
MMFSSAMLLG MLGGNMLVIV IAKFEIPIDV FTLLFAMYNF SVVGVLSIFY QKGTPMWLTQ
TYLVATSVIM AWQLGQFPEW STWALVIVLA FYDLCAVLTP CGPLKWLVNL VQQEGRPLPG
LLYEAEIRRN HSGHTAQPVR ENVYYQCESE IPLRLGSPRD VPEGPTSSTH TSLTPRQAQL
RARLIEFYSK HNPSAISRVD KILERYHGRE TELWHDLYQK YVTDQGEVDE TIKLGLGDFV
FYSVLVSRAA KYDFSAMIGC LVSVLMGLGG TLFLLGIYQK ALPALPISIL LAVMMYFWLR
VVFVDFASSA LNLGVPL
//
