ID W2H358_PHYPR Unreviewed; 1388 AA.
AC W2H358;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Transcription elongation factor spt6 {ECO:0008006|Google:ProtNLM};
GN ORFNames=L914_06301 {ECO:0000313|EMBL:ETM49402.1}, L915_06372
GN {ECO:0000313|EMBL:ETK89657.1}, L916_06316
GN {ECO:0000313|EMBL:ETL43059.1}, L917_06184
GN {ECO:0000313|EMBL:ETL96230.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETK89657.1};
RN [1] {ECO:0000313|EMBL:ETL96230.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHvinca01 {ECO:0000313|EMBL:ETL96230.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CHvinca01.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETK89657.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ02B3 {ECO:0000313|EMBL:ETK89657.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ02B3.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETL43059.1, ECO:0000313|Proteomes:UP000053864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ05E6 {ECO:0000313|EMBL:ETL43059.1,
RC ECO:0000313|Proteomes:UP000053864};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ05E6.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ETM49402.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAC_01/95 {ECO:0000313|EMBL:ETM49402.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica IAC_01/95.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SPT6 family.
CC {ECO:0000256|ARBA:ARBA00009253}.
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DR EMBL; KI685659; ETK89657.1; -; Genomic_DNA.
DR EMBL; KI685659; ETK89658.1; -; Genomic_DNA.
DR EMBL; KI672225; ETL43059.1; -; Genomic_DNA.
DR EMBL; KI672225; ETL43060.1; -; Genomic_DNA.
DR EMBL; KI678935; ETL96230.1; -; Genomic_DNA.
DR EMBL; KI678935; ETL96231.1; -; Genomic_DNA.
DR EMBL; KI692186; ETM49402.1; -; Genomic_DNA.
DR EMBL; KI692186; ETM49403.1; -; Genomic_DNA.
DR EnsemblProtists; ETK89657; ETK89657; L915_06372.
DR EnsemblProtists; ETK89658; ETK89658; L915_06372.
DR EnsemblProtists; ETL43059; ETL43059; L916_06316.
DR EnsemblProtists; ETL43060; ETL43060; L916_06316.
DR EnsemblProtists; ETL96230; ETL96230; L917_06184.
DR EnsemblProtists; ETL96231; ETL96231; L917_06184.
DR EnsemblProtists; ETM49402; ETM49402; L914_06301.
DR EnsemblProtists; ETM49403; ETM49403; L914_06301.
DR VEuPathDB; FungiDB:PPTG_02605; -.
DR Proteomes; UP000053236; Unassembled WGS sequence.
DR Proteomes; UP000053864; Unassembled WGS sequence.
DR Proteomes; UP000054423; Unassembled WGS sequence.
DR Proteomes; UP000054532; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR Gene3D; 1.10.10.650; RuvA domain 2-like; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 1.10.10.2740; Spt6, Death-like domain; 1.
DR Gene3D; 1.10.150.850; Spt6, helix-hairpin-helix domain; 1.
DR Gene3D; 1.10.3500.10; Tex N-terminal region-like; 1.
DR Gene3D; 3.30.420.140; YqgF/RNase H-like domain; 1.
DR InterPro; IPR041692; HHH_9.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR049540; Spt6-like_S1.
DR InterPro; IPR042066; Spt6_death-like.
DR InterPro; IPR032706; Spt6_HHH.
DR InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
DR InterPro; IPR035420; Spt6_SH2.
DR InterPro; IPR035018; Spt6_SH2_C.
DR InterPro; IPR035019; Spt6_SH2_N.
DR InterPro; IPR028231; Spt6_YqgF.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR017072; TF_Spt6.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR PANTHER; PTHR10145; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR PANTHER; PTHR10145:SF6; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR Pfam; PF14635; HHH_7; 1.
DR Pfam; PF17674; HHH_9; 1.
DR Pfam; PF14641; HTH_44; 1.
DR Pfam; PF14633; SH2_2; 1.
DR Pfam; PF21710; Spt6_S1; 1.
DR Pfam; PF14639; YqgF; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158832; Tex N-terminal region-like; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 189..286
FT /note="Helix-turn-helix DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF14641"
FT DOMAIN 605..740
FT /note="Transcription elongation factor Spt6 YqgF"
FT /evidence="ECO:0000259|Pfam:PF14639"
FT DOMAIN 754..855
FT /note="Transcription elongation factor Spt6 helix-hairpin-
FT helix motif"
FT /evidence="ECO:0000259|Pfam:PF14635"
FT DOMAIN 867..899
FT /note="HHH"
FT /evidence="ECO:0000259|Pfam:PF17674"
FT DOMAIN 988..1062
FT /note="Spt6-like S1/OB"
FT /evidence="ECO:0000259|Pfam:PF21710"
FT DOMAIN 1134..1327
FT /note="Spt6 SH2"
FT /evidence="ECO:0000259|Pfam:PF14633"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1336..1388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..85
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1336..1370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1371..1388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1388 AA; 159049 MW; 653901425B8F31B8 CRC64;
MLVRENMGMD TGPTRSDSED EDMGRSSRKV KTEDDSGLMS RELSYRMFGD SDEEEEDSAP
QRANNYLGND EYESDDIDEF IVDDDEEGRE GPRRRRKQEP IPASMQGPSV YQMGEAEELF
GDMDGFLEAT SGKIPEEMPA KSKKAILLEK FEPSVLKEHM MTSDVVAVRD KDLPERYQYL
FKNREFPDAE DRAEESEWIS DFIIKNLERR GQRSSAASRG EIVSAIDTVL RFYHDEKLEP
AFVQRYYKEY WKVVGLHTEN LYEILDLDVK WDKLNRKRKS FQSGIQRVVD SSNAKESAFV
RKCYEQLFST PDEKIYKDLS EFFGLDALES SGQSKENSDK KYRRPVRRTF YQICTKAGLR
PVSLAFTMNS SVLGGIVAGV DHEDTIRDVP TPDESPGVLA QKYTTKEFPT VDDVMKGARH
IAASKVAAEP NVRKCIRELY RQNAVLSTEA TAKGREEIDE FHYCHGLQYI EKMPVLDVFE
AGDLWLKISR AEKEGLLTTT IINEKAQDLM DPLEPIYLSP NNDSDEEWQS QRHLVLQEAI
NSFMILSFEN ELKRDLTVAS RDVVVKMCGN ALRERLSVRP YEPSEGVDPF IVSIWVESSM
DSIAHIVALD VNGEMVDKTE GYCKRDVNNI EKLSATLLKF LTEHSQTHVV VINVSAGMKC
MDMGGVVDEV RRLLGRDDAS RFGNGDGHDF LDIVFLKDDV ANMFSRSKRA DQEFPEESEY
VRAAICLGRY LRNPASELCA MWGNVALNEP NRGRELLFLN VHMMQHSLVK DLLLREYDRV
FVQVINKYGV DINLLANHKH TSYQLQFICG LGPVKAASVL DKVRAKNYVE RRQELLSKGF
VGKIVYRNCA GFIRIRERDA LREAPLNPLD DTRIHPESYY MAVKICGDAN NNSTIDMYDP
NHYSYAVEDT MYQSASAIRS RNAPPNTRLG DAEIQDVLSE LDLSAYAGRL ELQKKGPKLL
TLEYIKRELR YPYFDKRAKY QVPKDEDLFF LLNGETRETL RIGMIVPATL LHMSGDDFVR
VRLQSGMRSS LHRDRLPDYL MDVRPQSFPK GITVNAKILA IQADREGRYE LQLGCNRRSL
IDMSMCFYPE RFPRYTNGKL VENDSMERVD RLVNEPPVEE DKTTFTQATR VPGAHTSRRK
KRQIAHPLFR NINCQTAMQC LREQPVGEVV IRPSTLGTDH LTLTWKMLDG VYRHFDIQEK
DKPSEARIGQ TLIIKEEKYE NIDELIARFV DPMNSLVDDV VRYKYYKNAP KESVEEDLIK
QKKEHPSRIP YALHVYSKFP GCFSITYIAR ETPRSCHMEV KSGGYRFFGR IESSILPTLS
QALQFFKMKA LVAPSSNSSR PDSYHQHDSS SGPFAQRSSA PYSGSGSRPR QSSRWDDRRG
GDAGGRRW
//
