ID W2KIH5_PHYPR Unreviewed; 6076 AA.
AC W2KIH5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
GN ORFNames=L917_15700 {ECO:0000313|EMBL:ETL84439.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETL84439.1};
RN [1] {ECO:0000313|EMBL:ETL84439.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHvinca01 {ECO:0000313|EMBL:ETL84439.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CHvinca01.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI681777; ETL84439.1; -; Genomic_DNA.
DR EnsemblProtists; ETL84439; ETL84439; L917_15700.
DR VEuPathDB; FungiDB:PPTG_23829; -.
DR VEuPathDB; FungiDB:PPTG_23830; -.
DR Proteomes; UP000054423; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd00063; FN3; 17.
DR Gene3D; 2.60.40.2030; -; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 22.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF14; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR Pfam; PF03160; Calx-beta; 4.
DR Pfam; PF00041; fn3; 8.
DR SMART; SM00237; Calx_beta; 3.
DR SMART; SM00060; FN3; 26.
DR SMART; SM00710; PbH1; 22.
DR SUPFAM; SSF141072; CalX-like; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 15.
DR SUPFAM; SSF51126; Pectin lyase-like; 6.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS50853; FN3; 21.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 5363..5384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5473..5492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5526..5550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5702..5722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5746..5775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5885..5903
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5915..5934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5946..5967
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 202..299
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 404..515
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 520..613
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 618..708
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 712..803
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 807..895
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 897..991
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1229..1322
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1324..1420
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1425..1522
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1523..1623
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1634..1721
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1727..1818
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1820..1917
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2029..2119
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2361..2455
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2459..2553
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2842..2938
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2943..3035
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3160..3250
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3255..3350
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 3624..3643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6076 AA; 650415 MW; 8DC5E5D8EE4CB764 CRC64;
MTVYEYMGST GVVIVRNGGV SGQVSVTLIS TISSSIRGNR LQKAVTFADG VDNAIVLVNI
RSSSAYGTRR FVLTLTNPTN GASVDSRNLT VTVLDQGNLS PPGRPLLAQV SSTGGCIGLE
LGLPTYLGGW YIGTSIMWHI RVGTGFSYTF EKSDYVVSSI SRIDACGLDL NTSYTISAAL
RTDSGTSESR IIDGFTQALS TPTQVLELLA SPVTSGYAQL SWKAPFDTGG MPITTYEITV
LNRATNEQRI IQVPGSNLTV AISFLLASTG YMFTVQAVNE GGLVGPDTRT SVWTDSGSLP
KQPPVPELIS ATGGALRVRV LAPVDCGGSF LMHYAVNVAR HTGGILAYRQ YELGTVQSPS
YDSNVANISI YGLLSNSEYF ITVSVENTQG WSWISEEKIY KTTGPTPVSG IPAPIVALED
PGELTLQWNS PLDSGGLGIV GYSIQSRHKY PNGSWSVPEI VYDVRTSLVR TALIMNIVAN
TEYVFSVSGY NFRTLCRPDE NITPSDELHI TTQSASVPSQ PKNFRMVHVT GGSITLVWDP
PRSSGGEALL WYLIKGGVKY SQLEAMANVS ATMNSLTLYG FDASTFYEFA IAGENSRGCG
LYSPSLYVST GSVSAPGPPK SLHQIPVASG GIIRLAWEAP KDSGGVKIQQ YNILRDDNVV
SVVIAVNGTT TFQDQNNILA NKDYNYSVFA SNDVATSTNP ATITAHSGVA SVPGAPSATI
EAGSGFIRLE LIPSPDSGGI PFLLFDLTVM RGSVPVDSYN TTRSVFTVTG LYADVLYAVL
IQTVNARGKS KTTTLTTSTT AATIPDKMSL PRLVNVTGGR LQFEVLPPPN FGGRGVVEYR
FYVNETLNEA IRNSETAYDV VGLTALTFYA VAVSATNVVG EGEQSDSLIV TTDTVTAPGQ
VWSLKLISKT YEAIEVEWMM PYDTGGNVTA VQFDVEINSS TSDRNLVIST TNRVALSGLE
PATLYTIQVR AFNLIGEGPW CTSISVTTDP VSPGVIDFEK DAVDVLEDAG SITLTLIRSM
GGYMPATCTF TTVDGTAIAG DHYVQTSGQV NFSRGTNSQQ ITIPIIDNGM TNDPDQYFSV
SIEEYDNESG AIGEISWVNV TITDDGDAGV VAFEQALYTV SESVSTLTVT IVRSGKFSGS
GTFAIKPVDA DNGAIEGVDF KIPSELVILS DQETQSSFNI TIINDSTYQE RKLFRLKLDV
VSGRVAIADP AAFLTIEILD DGDASPPGLP TSVQVIAVSG GMINLLWVAP EYLGAKNPGE
LSYSVRVVEV QSGSTWEQSI KALNLLIPQL KSRAAYGFSV AAKTAFFLGE YTSSVPTLMK
EPTPPSSPMG VRVLSQTGGM VTLSWSPPFD SGGVDITSYR VNISTSADNK TLGNYITVRN
TISIGKLDPV TNYCATVESI NSYQYVGEAS TTVSFTTTSA SMPGKPTSLV ITKATGGALL
VEMAPPLDTG GAPILYFTLF MTSAQYPTVF RQVYQGATSS FYATRLLYST TYKFQYKVTT
KVGMSELSDI FVAATKFLTL PDEAQNLAIV SRTGGSVTLS WTQPVDFGGT DITAYDVAFF
LGYEVKSQFQ QRISGVSVNA TLVTAKVVGL QANSTYGFSV SGVNDVSVCE DPSAIRSRTI
LYSRTNPAVS LPDTPRGLSV VFVTSGTQTI QWIASEDAGG GSFVAYILYS DTDTVLYNGT
STTFTRGSLV KSTVYGYTVC AWNSAGSGVQ SSRIFARTKT DIVAPSQPLN LAQTSHSGGS
IGLTWQTPLD SGGDTISGYK LFRNGTWRAD IVADSATMTY LDDQGLAALQ YYVYTIRATN
SIGLGAVSEV LIASTASATV PSAPTRLDVF AKGGNLSATW SPAANSGGMP LTFFRLVVKD
DTGVVLDEVT ATTQVSYITY GIRANTTYTV LLTSGNEIGE SSATTQTIMN GAAVRPATPQ
VPEQHLEMTG LARWMIVLKL YFPIDNGGAP LKGLNLYQNG SRIRTVDATS QTEPGDTTIR
FTLVEIGPLH AGFTYHFSTS ALSSVETIGE GGRSDTVKIV MDPANLPSAP NNLRVVLRTA
FSVFFEWDKS DDKGGDDVVY EIAFNNLNTS EPGQVETNTT AVEVSKLIPG NDYLFRVRAR
NSAGTSDWTS DLPAQTDVTQ RGVITYKLAS STVFENVTSV TVQLLRVNGS SSTITCKYSN
TSGTAIYGRD YSLPPDSEHS FTFVGELIEK SFDVQIINND IYEPIPRTIG LTLTDTTPDR
SDPFPPTPII VIIVDDGDAG MISFVVTEVT VLENARIVSL PLQREYGKST AVSVQILVYT
GLTSTTQPDI GFRLPSTTVD FVDGQTSSSA SIVIKDNDVY DFPYLCFYLT LEIAAGAARI
GTNNVIKVVV QDDGDRSMPG AMKAPTLDKA TGGMLRLKWE PPVNVGGQNV WITGYNVSIR
TVKGTTWIIT PTNATVIPFG GLNVLTEYNF SISAINSIGR GVDSSSVTFS TTKLTAPGPP
EHIALLNRTG GLLTVAVAPP SDSGGASITG YVVHLAEQGS DFKMAYNGTG HLSSIIPVSV
TKPNTAYIIR AQAINVVGVG EMSEPFSFES GPLSRPGPPR LPAIQSSRTG GAIKLDLLPP
LDTGGHENIS YMIYYRKQGL RERFRQAYYV ANGLKITIFR LGADTTYDMV AVSHLEDSAN
VITWGRISVS DSRITLSDNV ATEIVKSGYF DFGGYLFEVD TTQVQSNNTI AYSASLSTDF
GAIAASSLQN GDEYDVFVRG PYSDVANYTT VAPTRPGMPP EPDLDYATGG ALHIRISWPD
DTGGIPITGY EFYINNKTVE GTLYHYISQG DFELKVTVEI GGLVPENNYS FYYIPLNDAS
ACAGDDEDIP KQVIFSTDVA SKPMPIQLIR STGATGGGIH VEVKPPNDRG SDQNLTYQIY
MSLSRSIPIW TRIYNDKDIS YWQTKLQKVT EYLFMASCMN KVGYSSNSSI YPLRTTLISA
PGPPGDLTLI NATGGMIKFS WKSPDDDGGS PITYYSIHAQ DTSGNPELAL ESLLPEISFG
GLLANRVYEF KVFAGNSLGI GSDASVKRFS TTLPTPPSLP GDPVVLQSSG GSATLAIQVP
NDTGGVNIDD LVCTVYENGF KVPVDAVRRL QNMPITVSRT RRLATMEVAA DGGGFIYLQA
GGLLPSTAYS FTIQISNDVG VSDTTNGIAT ATSVATVPGA PDPPTITLAT GGALTLSWTD
PVDTGGVPLT SYHLSMARLG EEVGSCEGMI RTCTVGDLLS ITDYTVTIFA YNTVGVSPPS
EEVTFTTEPT SLPLAPQDVH VAELSNTSVT IHWDPCIDFG GGYVDTYRLN IVQISNPSVT
FSGITPVDEQ ILTIENLTPQ TEYTATVRAV TGAGESGEAS KIIFFRTPLY AHQPSPPQVG
CHSRKVANVF WEAEDDAVSY RLFRDGEFYV DNGEDITYED EIVLGKTYIY QVQVIRFDGS
ISALSETTTF TAMTPVSSGF DCVGNKGHIH WHDYKNLDSE TWTITPQNQA GVLISFSLFW
LECDHDSLTI SVTKGGVTKQ LWKGGCHRKG DFVVSTGPGL DSVALSFTSD GSVAYEGMAL
HYETVDASDA VESVSAPCPL SPTGFCSLNG ACRKGTCSCF SGFIGESCTN AVICPEDLTT
CTSTTCDPVC LHSQNDVIVV SENGDDTQGT GELMDTSTSG TDPKAVKSLR RALELATSGQ
TILLYPGIYT GVDNCGVTVS TASLLIRGLR GPIPTIVDCK NILRGLIIIS DAAPNRLEGF
RIQNTLASTD GGAIKVTDTA VEMKNMVITN ANSRQNGGAI YAYQSQLTFT NVEITKCSAA
KGGAIFLDNS DLILDDSIIT LSSASEGGGI YAQNSVSVSG DKDSNLWQNH ASINGGGLCI
SGSFTGTTLN VLENTALVGA GLTATSGSST LSGMKVIGNR ATNHGGGIAM LNSANLVLQN
STIQTNHADR NGGGVYILSN GSFENTLASE ISNCTAASGG GFYTGDWSRP TVRNLRVVSS
SATTSGGCAA FSCSSATVTN PSFEKCDAAI GGGVYVDAGS KVLLLQASIA ECTATNGAGM
YIGSSSVIGG SDVSSVVRDS HADSAAGGVY ITGFHSSIEF FDVQNCSASI GGGVVAQEAS
SATMKSVQVV NNKATTSGGG LHAQNSTIQV EPVTVSSNRA VVGGGVYAID SSLSGIITVD
QNNGERGGGV ATSGISLLEG ATISANTASQ RGGGVSVETG LFSLRSTIIQ SCSVPQGVGG
GISIVDADVK HYALKIESCA SIRGGGIYVN SSSFYQYPTE ESTGTSLNAA SLTKNRAVEY
GGSVFVDGEE TTVSDLVITE SHAPFGGGLA AQDATSCVVL NADISYSSAS TSGGGLLFGS
GTSCVIRDSW VMNNQARESG GGVMIFEATL YHSNVDISNN VAPTAGGVYL NSVLYSASLL
SWDDGATQRS RIDANIIEPI GGNGANVVMN CTSNCTLSGC VISGANLQFG QGAGVFVLGR
GNAVISNSLV ANNSAIKGGG IAVSDAEKTV LENVGFIGNI ATDSGGGLWA ESSAFLPEVD
LMSCVFYNNS AKTSGGAISL YGVYLYSSVL LVMENHAGNS ESGIGGGLFS DKRVNPDRPS
SVMADTWLFL SNDAPVGGSI AGVKSSEISL LDANITRDTG RFFTGTWPHL FSKLVGFEHV
EGRAQNKVEV QKGDLVYLSD RDSVLELLSS FATQGLAAAG GGIYINANAF FYSQDSEISS
NTANERGGSV CLSNSAQAYF TSVKVILSDS KTSGGGIYVE SSSKLYAENS NISDNFADDS
GGGIFIDTGD KNAVTLNGSF IERNFAHGEG CGVFVGREAI LAGYKSQFIG NGGVTTSGKN
EGGGAISCVD GIVKLTSCTF INNTALVGGA IHFDRGGSAA IMSSVFEGNT ADQNGGAIAT
SVKAKVTIAL QTLFENNVAH FGGAMAVSGT STFILTSVDF RSNRASEVGG ALFITDQAKV
TMKAGELAGN IAVFGGALYS DDHSSTSVSD AKFIRNSAFT RGGAIYYQSI DNATITRITC
KENTAPSGGC IFWVSEDEDL TPTYPCTSCT MEFNEVYDIA TNTRDVQVMW WPENMTSGVP
ILEPPDEESI QAIKTRNESL ERKMHVWPRL KAVDLYGQVE VLDNQTECMV SDGLCSEQTE
RLLFEPRALI RSAGGVISYR GASFTAANRT PEEGIYTTDI SCTLPRSERR FFVQSVKLLP
CQPGYSVNQG VCERCPKNMY SLDGLKCFDC PSGAKCNMNV RRGTDTIAEE LGTVSPRTEE
GYYLFSAPAT KQESSCNKPS LWKDEDPCKN LALENPTKNL SDMIYECSNL NDFNVYWSAD
RLFSCLSGKS FYTCDVEGAC QADVTVQMLA HAAAVSTVSC TSGYDLAICS VCADGYKRAR
DNSCLPCNEA NAEVRASIKW QNFVIPVLLV LALIGGVFSV RFYLRDLTEI GLLAKAEADR
RLKAPDSKKG GHIALRAGAK YRRQSMAVVG RVDQVKNKIT AFFKTYQSRN VKMVFGVDVS
PPPRTFPVNP SKFKIFIGFF QIFGNFQSSF VVKWSSNVQD VMNISQKFNL DLVAIAGIDC
VVTKNFYFEF TVTVILVVLA LTVITAYFYA GMRSYRSKLQ LIPRNCLRCG LPVLESEVIQ
NDDESFNPLR LLRSWWRTYN FYKRSGSSSP VEAAKGGPEN EGTAALSTLK ETRALKRKFG
MSQVRTPYLG LFRSVHAKCP TKRHKLSGAM LDRTIRSNLR VWQARVKLRM NYLTYRNKCL
KLYCWIALFL YPSVSKTILT VYNCQEVGDV FYLVADRRLI CYNAQWAVFG MIATIGVIVW
VVGIPFFFGL LIWLAQDRGV AARIKLLRKP QMRMQRHKWL KEVEEQQTAD GRFVRDMKNI
EVQDEELTKY MKRKNLTDST VQARLGFIYA EYTHDYWWFE VVDLSRKLFL SGVIVFVENG
SVEQVLLALA VCLTTMWFLL YFQPYDGYSD NLIASITQLQ LFFTLWLGVM IRLNDLNVES
LINVQLLSFL LVGTCIAVTM FGISMIIGEG LAESRRIFAE TTAQRKKQVQ KEVRKRWFQA
YNYAAYEAQM LRYGGQLSFD NVSVPAMLEA FRRTKLNEEE DPEYASMMPK IEEGDMDESI
IESHPEYTTS RVNAGR
//
